AIMC Topic: Lethal Dose 50
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Safety assessment of the ethanolic extract of Siparuna guianensis: Cell viability, molecular risk predictions and toxicity risk for acute and sub-chronic oral ingestion.
Journal of ethnopharmacology
Apr 5, 2025
ETHNOPHARMACOLOGICAL RELEVANCE: The species Siparuna guianensis Aublet (family Siparunaceae) is traditionally used by indigenous peoples and riverine communities in Central and South America to treat migraines, flu, respiratory diseases, fever, pain,...
Using the super-learner to predict the chemical acute toxicity on rats.
Journal of hazardous materials
Oct 28, 2024
With the rapid increase in the number of commercial chemicals, testing methods regarding on median lethal dose (LD) relying animal experiments face challenges such as high costs and ethical concerns. Classical quantitative structure-activity relation...
A comprehensive prediction system for silkworm acute toxicity assessment of environmental and in-silico pesticides.
Ecotoxicology and environmental safety
Jul 18, 2024
The excessive application and loss of pesticides poses a great risk to the ecosystem, and the environmental safety assessment of pesticides is time-consuming and expensive using traditional animal toxicity tests. In this work, a pesticide acute toxic...
In silico prediction of chemical aquatic toxicity by multiple machine learning and deep learning approaches.
Journal of applied toxicology : JAT
Jun 26, 2022
Fish is one of the model animals used to evaluate the adverse effects of a chemical exposed to the ecosystem. However, its low throughput and relevantly high expense make it impossible to test all new chemicals in manufacture. Hence, using in silico ...
In silico prediction of chemical acute contact toxicity on honey bees via machine learning methods.
Toxicology in vitro : an international journal published in association with BIBRA
Jan 11, 2021
In recent years, the decline of honey bees and the collapse of bee colonies have caught the attention of ecologists, and the use of pesticides is one of the main reasons for the decline. Therefore, ecological risk assessment of pesticides is essentia...
Anthelmintic effect and tissue alterations induced in vitro by hydrolysable tannins on the adult stage of the gastrointestinal nematode Haemonchus contortus.
Veterinary parasitology
Dec 24, 2018
Haemonchus contortus constitutes a severe problem for ruminant's production, it is the most frequent nematode parasite both in template and tropical regions, induces economical losses, and shows increasing resistance to currently available anthelmint...
Deep Learning Based Regression and Multiclass Models for Acute Oral Toxicity Prediction with Automatic Chemical Feature Extraction.
Journal of chemical information and modeling
Oct 27, 2017
Median lethal death, LD, is a general indicator of compound acute oral toxicity (AOT). Various in silico methods were developed for AOT prediction to reduce costs and time. In this study, we developed an improved molecular graph encoding convolutiona...
Identification and designing an analgesic opioid cyclic peptide from Defensin 4 of Mesobuthus martensii Karsch scorpion venom with more effectiveness than morphine.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Jul 1, 2025
Considering the limitations of use and side effects of existing analgesics, the discovery of new analgesics is necessary. Venoms of organisms are an important source of analgesic peptides. In this study, using computational biology methods such as mo...
Prediction of Oral Acute Toxicity of Organophosphates Using QSAR Methods.
Current computer-aided drug design
Jan 1, 2021
AIMS: Prediction of oral acute toxicity of organophosphates using QSAR methods.
Report: Evaluation of the scolicidal effects of Nectaroscordum tripedale extract and its acute toxicity in mice model.
Pakistan journal of pharmaceutical sciences
Nov 1, 2016
Current scolicidal agents, which have been used for inactivation of protoscoleces during hydatid cyst surgery are associated with adverse side effects. This study aims to evaluate the in vitro scolicidal effects of Nectaroscordum tripedale L. leave e...
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