SIGNIFICANCE: Circulating tumor cells (CTCs) are important biomarkers for cancer management. Isolated CTCs from blood are stained to detect and enumerate CTCs. However, the staining process is laborious and moreover makes CTCs unsuitable for drug tes...
Studies in health technology and informatics
Jun 6, 2022
Data augmentation is reported as a useful technique to generate a large amount of image datasets from a small image dataset. The aim of this study is to clarify the effect of data augmentation for leukocyte recognition with deep learning. We performe...
This work demonstrates a multi-lens microscopic imaging system that overlaps multiple independent fields of view on a single sensor for high-efficiency automated specimen analysis. Automatic detection, classification and counting of various morpholog...
Artificial cells, nanomedicine, and biotechnology
Dec 1, 2021
BACKGROUND: Machine learning (ML) algorithms have been widely used in the classification of white blood cells (WBCs). However, the performance of ML algorithms still needs to be addressed for being short of gold standard data sets, and even the imple...
Proceedings of the National Academy of Sciences of the United States of America
Jul 13, 2021
Forward genetic studies use meiotic mapping to adduce evidence that a particular mutation, normally induced by a germline mutagen, is causative of a particular phenotype. Particularly in small pedigrees, cosegregation of multiple mutations, occasiona...
SIGNIFICANCE: Researchers have made great progress in single-image super-resolution (SISR) using deep convolutional neural networks. However, in the field of leukocyte imaging, the performance of existing SISR methods is still limited as it fails to ...
Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
Jun 25, 2020
The number of white blood cells in the leucorrhea microscopic image can indicate the severity of vaginal inflammation. At present, the detection of white blood cells in leucorrhea mainly relies on manual microscopy by medical experts, which is time-c...
Journal of the Optical Society of America. A, Optics, image science, and vision
Nov 1, 2018
Unlike urine or blood samples with a single background, human fecal samples contain large amounts of food debris, amorphous particles, and undigested plant cells. It is difficult to segment such impurities when mixed with leukocytes. Cell degradation...
MOTIVATION: Recent advances in mass cytometry allow simultaneous measurements of up to 50 markers at single-cell resolution. However, the high dimensionality of mass cytometry data introduces computational challenges for automated data analysis and h...