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Linear Energy Transfer

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MALDI-Imaging for Classification of Epithelial Ovarian Cancer Histotypes from a Tissue Microarray Using Machine Learning Methods.

Proteomics. Clinical applications 30471200
PURPOSE: Precise histological classification of epithelial ovarian cancer (EOC) has immanent diagnostic and therapeutic consequences, but remains challenging in histological routine. The aim of this pilot study is to examine the potential of matrix-a...
Carcinoma, Ovarian Epithelial Discriminant Analysis Female Humans Linear Energy Transfer Machine Learning Middle Aged Molecular Imaging Ovarian Neoplasms Proteomics Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Support Vector Machine Tissue Array Analysis
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Deep learning-based synthetic dose-weighted LET map generation for intensity modulated proton therapy.

Physics in medicine and biology 38091613
The advantage of proton therapy as compared to photon therapy stems from the Bragg peak effect, which allows protons to deposit most of their energy directly at the tumor while sparing healthy tissue. However, even with such benefits, proton therapy ...
Deep Learning Linear Energy Transfer Monte Carlo Method Proton Therapy Protons Radiotherapy Planning, Computer-Assisted Relative Biological Effectiveness
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Deep learning based linear energy transfer calculation for proton therapy.

Physics in medicine and biology 38714191
This study aims to address the limitations of traditional methods for calculating linear energy transfer (LET), a critical component in assessing relative biological effectiveness (RBE). Currently, Monte Carlo (MC) simulation, the gold-standard for a...
Deep Learning Humans Linear Energy Transfer Male Monte Carlo Method Proton Therapy Radiotherapy Dosage Radiotherapy Planning, Computer-Assisted
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A deep-learning-based surrogate model for Monte-Carlo simulations of the linear energy transfer in primary brain tumor patients treated with proton-beam radiotherapy.

Physics in medicine and biology 39019053
This study explores the use of neural networks (NNs) as surrogate models for Monte-Carlo (MC) simulations in predicting the dose-averaged linear energy transfer (LET) of protons in proton-beam therapy based on the planned dose distribution and patien...
Brain Neoplasms Deep Learning Humans Linear Energy Transfer Monte Carlo Method Proton Therapy Radiotherapy Dosage Radiotherapy Planning, Computer-Assisted
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Online Adaptive Proton Therapy Facilitated by Artificial Intelligence-Based Autosegmentation in Pencil Beam Scanning Proton Therapy.

International journal of radiation oncology, biology, physics 39307323
PURPOSE: Online adaptive proton therapy (oAPT) is essential to address interfractional anatomical changes in patients receiving pencil beam scanning proton therapy. Artificial intelligence (AI)-based autosegmentation can increase the efficiency and a...
Artificial Intelligence Feasibility Studies Humans Linear Energy Transfer Male Organs at Risk Prostatic Neoplasms Proton Therapy Radiotherapy Dosage Radiotherapy Planning, Computer-Assisted Rectum Retrospective Studies Tomography, X-Ray Computed Workflow
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GANDALF: Generative ANsatz for DNA damage evALuation and Forecast. A neural network-based regression for estimating early DNA damage across micro-nano scales.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) 40117723
PURPOSE: This study aims to develop a comprehensive simulation framework to connect radiation effects from the microscopic to the nanoscopic scale.
Algorithms DNA Damage Escherichia coli Linear Energy Transfer Neural Networks, Computer Protons Regression Analysis
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