AIMC Topic: Microscopy, Atomic Force

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Quantifying complexity in DNA structures with high resolution Atomic Force Microscopy.

Nature communications Jul 1, 2025
DNA topology is essential for regulating cellular processes and maintaining genome stability, yet it is challenging to quantify due to the size and complexity of topologically constrained DNA molecules. By combining high-resolution Atomic Force Micro...
Escherichia coli DNA Nucleic Acid Conformation Animals Xenopus laevis DNA Replication Microscopy, Atomic Force Plasmids
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Advancing High-Throughput Cellular Atomic Force Microscopy with Automation and Artificial Intelligence.

ACS nano Jan 30, 2025
Atomic force microscopy (AFM) has reached a significant level of maturity in biology, demonstrated by the diversity of modes for obtaining not only topographical images but also insightful mechanical and adhesion data by performing force measurements...
Animals Microscopy, Atomic Force Automation Humans Artificial Intelligence
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The Influence of Surface Treatment on the Color of Enamel and Dentin: An In Vitro Study Using Machine Learning-Based Analysis.

Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] Jan 6, 2025
OBJECTIVE: To investigate how surface treatment affects the color of enamel and dentin, and to evaluate whether the color differences are acceptable.
Phosphoric Acids Dental Enamel In Vitro Techniques Dentin Color Humans Microscopy, Atomic Force Surface Properties Machine Learning Acid Etching, Dental
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Detection of Human Bladder Epithelial Cancerous Cells with Atomic Force Microscopy and Machine Learning.

Cells Dec 26, 2024
The development of noninvasive methods for bladder cancer identification remains a critical clinical need. Recent studies have shown that atomic force microscopy (AFM), combined with pattern recognition machine learning, can detect bladder cancer by ...
Microscopy, Atomic Force Urinary Bladder Urinary Bladder Neoplasms Epithelial Cells Humans Cell Line, Tumor ROC Curve Machine Learning
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Determining structures of RNA conformers using AFM and deep neural networks.

Nature Dec 18, 2024
Much of the human genome is transcribed into RNAs, many of which contain structural elements that are important for their function. Such RNA molecules-including those that are structured and well-folded-are conformationally heterogeneous and flexible...
Signal-To-Noise Ratio Nucleic Acid Conformation RNA Microscopy, Atomic Force Humans Neural Networks, Computer Unsupervised Machine Learning Models, Molecular Deep Learning
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Deep learning-based denoising for unbiased analysis of morphology and stiffness in amyloid fibrils.

Computers in biology and medicine Nov 22, 2024
Understanding the morphology of amyloid fibrils is crucial for comprehending the aggregation and degradation mechanisms of abnormal proteins implicated in various diseases, such as Alzheimer's disease, Parkinson's disease, type II diabetes, and vario...
Humans Microscopy, Atomic Force Image Processing, Computer-Assisted Software Amyloid Deep Learning
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Automated High-Throughput Atomic Force Microscopy Single-Cell Nanomechanical Assay Enabled by Deep Learning-Based Optical Image Recognition.

Nano letters Sep 20, 2024
Mechanical forces are essential for life activities, and the mechanical phenotypes of single cells are increasingly gaining attention. Atomic force microscopy (AFM) has been a standard method for single-cell nanomechanical assays, but its efficiency ...
Single-Cell Analysis Nanotechnology Microscopy, Atomic Force High-Throughput Screening Assays Humans Deep Learning
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Automated Bio-AFM Generation of Large Mechanome Data Set and Their Analysis by Machine Learning to Classify Cancerous Cell Lines.

ACS applied materials & interfaces Aug 20, 2024
Mechanobiological measurements have the potential to discriminate healthy cells from pathological cells. However, a technology frequently used to measure these properties, i.e., atomic force microscopy (AFM), suffers from its low output and lack of s...
Fuzzy Logic Microscopy, Atomic Force Machine Learning Algorithms Humans Cell Line, Tumor
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Cell recognition based on features extracted by AFM and parameter optimization classifiers.

Analytical methods : advancing methods and applications Jul 11, 2024
Intelligent technology can assist in the diagnosis and treatment of disease, which would pave the way towards precision medicine in the coming decade. As a key focus of medical research, the diagnosis and prognosis of cancer play an important role in...
Cell Line, Tumor Bayes Theorem Humans Algorithms Microscopy, Atomic Force Neural Networks, Computer Neoplasms Machine Learning
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On machine learning analysis of atomic force microscopy images for image classification, sample surface recognition.

Physical chemistry chemical physics : PCCP Apr 17, 2024
Atomic force microscopy (AFM or SPM) imaging is one of the best matches with machine learning (ML) analysis among microscopy techniques. The digital format of AFM images allows for direct utilization in ML algorithms without the need for additional p...
Microscopy, Atomic Force Neural Networks, Computer Algorithms Machine Learning Prospective Studies
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