AIMC Topic: Microscopy, Electron, Scanning
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A photonic crystal fiber-based fluorescence sensor for simultaneous and sensitive detection of lactic acid enantiomers.
Analytical and bioanalytical chemistry
Jan 13, 2022
A photonic crystal fiber (PCF)-based fluorescence sensor is developed for rapid and sensitive detection of lactic acid (LA) enantiomers in serum samples. The sensor is fabricated by chemical binding dual enzymes on the inner surface of the PCF with n...
Deciphering tumour tissue organization by 3D electron microscopy and machine learning.
Communications biology
Dec 13, 2021
Despite recent progress in the characterization of tumour components, the tri-dimensional (3D) organization of this pathological tissue and the parameters determining its internal architecture remain elusive. Here, we analysed the spatial organizatio...
Characterizing the Impact of Spray Dried Particle Morphology on Tablet Dissolution Using Quantitative X-Ray Microscopy.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Jul 3, 2021
For oral solid dosage forms, disintegration and dissolution properties are closely related to the powders and particles used in their formulation. However, there remains a strong need to characterize the impact of particle structures on tablet compac...
Neural Network Analysis of Electron Microscopy Video Data Reveals the Temperature-Driven Microphase Dynamics in the Ions/Water System.
Small (Weinheim an der Bergstrasse, Germany)
May 3, 2021
Real-time field-emission scanning electron microscopy (FE-SEM) measurements and neural network analysis were successfully merged to observe the temperature-induced behavior of soft liquid microdomains in mixtures of different ionic liquids with water...
Polypyrrole-Based Nanorobots Powered by Light and Glucose for Pollutant Degradation in Water.
ACS applied materials & interfaces
Mar 31, 2021
Novel photoactive and enzymatically active nanomotors were developed for efficient organic pollutant degradation. The developed preparation route is simple and scalable. Light-absorbing polypyrrole nanoparticles were equipped with a bi-enzyme [glucos...
Machine learning-based classification of mitochondrial morphology in primary neurons and brain.
Scientific reports
Mar 4, 2021
The mitochondrial network continually undergoes events of fission and fusion. Under physiologic conditions, the network is in equilibrium and is characterized by the presence of both elongated and punctate mitochondria. However, this balanced, homeos...
Machine learning-driven electronic identifications of single pathogenic bacteria.
Scientific reports
Sep 23, 2020
A rapid method for screening pathogens can revolutionize health care by enabling infection control through medication before symptom. Here we report on label-free single-cell identifications of clinically-important pathogenic bacteria by using a poly...
Determination of the Maturation Status of Dendritic Cells by Applying Pattern Recognition to High-Resolution Images.
The journal of physical chemistry. B
Sep 22, 2020
The maturation or activation status of dendritic cells (DCs) directly correlates with their behavior and immunofunction. A common means to determine the maturity of dendritic cells is from high-resolution images acquired via scanning electron microsc...
Automated diatom searching in the digital scanning electron microscopy images of drowning cases using the deep neural networks.
International journal of legal medicine
Aug 13, 2020
Forensic diatom test has been widely accepted as a way of providing supportive evidences in the diagnosis of drowning. The current workflow is primarily based on the observation of diatoms by forensic pathologists under a microscopy, and this process...
Characterization of Spray Dried Particles Through Microstructural Imaging.
Journal of pharmaceutical sciences
Aug 3, 2020
Spray drying is commonly used to produce amorphous solid dispersions (ASD) to improve the bioperformance of poorly water-soluble drugs. In this study, imaging techniques such as focused ion beam-scanning electron microscopy (FIB-SEM) and X-ray microc...
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