Malto-oligosaccharides, structurally diverse glucose polymers comprising 2-10 monosaccharide units, play vital roles in food science, pharmaceuticals, and glycobiology. However, their precise structural characterization remains challenging due to sub...
Adeno-associated virus (AAV) vectors are excellent gene-delivery carriers in gene therapy; however, improperly packaged capsids produced during manufacturing can reduce potency and raise safety concerns. We introduce a machine-learning-assisted, low-...
Bile acids are key signaling molecules implicated in various hepatobiliary and metabolic diseases. Synthesized via distinct pathways and undergoing diverse modifications, bile acids exhibit significant structural variation. The discovery of novel ami...
DNA/RNA modifications are crucial for biological processes. To understand their regulatory mechanisms, precise mapping and quantification of these modifications are essential. Although next-generation sequencing can detect the location and stoichiome...
On-demand access to information encoded in nucleotides lies at the heart of DNA/RNA applications. However, contemporary methods for targeted retrieval using PCR amplification or bead-based extraction, rely on Watson-Crick base pairing and pre-defined...
DNA nanotechnology uses predictable interactions of nucleic acids to precisely engineer complex nanostructures. Characterizing these self-assembled structures at the single-structure level is crucial for validating their design and functionality. Nan...
Proceedings of the National Academy of Sciences of the United States of America
Sep 15, 2025
Francis Crick's global parameterization of coiled coil geometry has been widely useful for guiding design of new protein structures and functions. However, design guided by similar global parameterization of beta barrel structures has been less succe...
Quantum transport-based DNA sequencing is emerging as a promising technique in genetic analysis, offering fast, precise, and scalable decoding of genetic information, holding significant potential for applications in human biology and personalized me...
DNA replication stress is a hallmark of cancer that is exploited by chemotherapies. Current assays for replication stress have low throughput and poor resolution whilst being unable to map the movement of replication forks genome-wide. We present a n...
The journal of physical chemistry letters
Aug 8, 2025
Single-molecule detection of post-translational modifications (PTMs) such as phosphorylation plays a crucial role in early diagnosis of diseases and therapeutics development. Although single-molecule surface-enhanced Raman spectroscopy (SM-SERS) dete...
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