MOTIVATION: Neoantigens, derived from somatic mutations in cancer cells, can elicit anti-tumor immune responses when presented to autologous T cells by human leukocyte antigen. Identifying immunogenic neoantigens is crucial for cancer immunotherapy d...
PURPOSE: Data on end-of-life care (EOLC) quality, assessed through evidence-based quality measures (QMs), are difficult to obtain. Natural language processing (NLP) enables efficient quality measurement and is not yet used for children with serious i...
MOTIVATION: Cancer is a very heterogeneous disease that can be difficult to treat without addressing the specific mechanisms driving tumour progression in a given patient. High-throughput screening and sequencing data from cancer cell-lines has drive...
Traditional cancer classification based on organ of origin and histology is increasingly at odds with precision oncology. Tumors in different organs can share molecular features, while those in the same organ can be heterogeneous. This disconnect imp...
Studies in health technology and informatics
Aug 22, 2024
Modern generative artificial intelligence techniques like retrieval-augmented generation (RAG) may be applied in support of precision oncology treatment discussions. Experts routinely review published literature for evidence and recommendations of tr...
Studies in health technology and informatics
Aug 22, 2024
The complexity of the cancer problem domain presents challenges not only to the medical analysis systems tasked with its analysis, but also to the users of such systems. While it is desirable to assist users in operating these medical analysis system...
Studies in health technology and informatics
Aug 22, 2024
Significant developments are currently underway in the field of cancer research, particularly in Germany, regarding cancer registration and the use of medical information systems. The use of such systems contributes significantly to quality assurance...
Studies in health technology and informatics
Aug 22, 2024
With cancer being a leading cause of death globally, epidemiological and clinical cancer registration is paramount for enhancing oncological care and facilitating scientific research. However, the heterogeneous landscape of medical data presents sign...
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