AIMC Topic: Nucleic Acids

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Mesophilic Argonaute-Mediated Polydisperse Droplet Biosensor for Amplification-Free, One-Pot, and Multiplexed Nucleic Acid Detection Using Deep Learning.

Analytical chemistry Jan 23, 2024
Detection of nucleic acids from a single multiplexed and amplification-free test is critical for ensuring food safety, clinical diagnostics, and environmental monitoring. In this study, we introduced a mesophilic Argonaute protein from (CbAgo), whic...
Deep Learning Biosensing Techniques Nucleic Acids Argonaute Proteins Nucleic Acid Amplification Techniques DNA
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Simple and Multiplexed Detection of Nucleic Acid Targets Based on Fluorescent Ring Patterns and Deep Learning Analysis.

ACS applied materials & interfaces Nov 16, 2023
Simple diagnostic tests for nucleic acid targets can provide great advantages for applications such as rapid pathogen detection. Here, we developed a membrane assay for multiplexed detection of nucleic acid targets based on the visualization of two-d...
Nucleic Acids Oligonucleotide Probes SARS-CoV-2 Nucleic Acid Amplification Techniques Deep Learning Fluorescent Dyes
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CryoREAD: de novo structure modeling for nucleic acids in cryo-EM maps using deep learning.

Nature methods Oct 2, 2023
DNA and RNA play fundamental roles in various cellular processes, where their three-dimensional structures provide information critical to understanding the molecular mechanisms of their functions. Although an increasing number of nucleic acid struct...
Models, Molecular RNA Deep Learning DNA Protein Conformation Nucleic Acids Cryoelectron Microscopy
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Deep Learning Assisted Surface-Enhanced Raman Spectroscopy (SERS) for Rapid and Direct Nucleic Acid Amplification and Detection: Toward Enhanced Molecular Diagnostics.

ACS nano Sep 13, 2023
Surface-enhanced Raman scattering (SERS) has evolved into a robust analytical technique capable of detecting a variety of biomolecules despite challenges in securing a reliable Raman signal. Conventional SERS-based nucleic acid detection relies on hy...
COVID-19 Testing Nucleic Acids Pathology, Molecular Spectrum Analysis, Raman Zinc Oxide Deep Learning Humans COVID-19 Reproducibility of Results
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Structure-based prediction of nucleic acid binding residues by merging deep learning- and template-based approaches.

PLoS computational biology Sep 6, 2023
Accurate prediction of nucleic binding residues is essential for the understanding of transcription and translation processes. Integration of feature- and template-based strategies could improve the prediction of these key residues in proteins. Never...
Cell Nucleus Nucleic Acids Deep Learning Walking Algorithms
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Programmable magnetic robot (ProMagBot) for automated nucleic acid extraction at the point of need.

Lab on a chip Aug 22, 2023
Upstream sample preparation remains the bottleneck for point-of-need nucleic acid testing due to its complexity and time-consuming nature. Sample preparation involves extracting, purifying, and concentrating nucleic acids from various matrices. These...
Magnetics Magnetic Phenomena Nucleic Acids Nucleic Acid Amplification Techniques Robotics
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Machine learning at the edge for AI-enabled multiplexed pathogen detection.

Scientific reports Mar 23, 2023
Multiplexed detection of biomarkers in real-time is crucial for sensitive and accurate diagnosis at the point of use. This scenario poses tremendous challenges for detection and identification of signals of varying shape and quality at the edge of th...
Neural Networks, Computer Machine Learning Fluorescence Nucleic Acids
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A deep learning based method for automatic analysis of high-throughput droplet digital PCR images.

The Analyst Jan 16, 2023
Droplet digital PCR (ddPCR) is a technique for absolute quantification of nucleic acid molecules and is widely used in biomedical research and clinical diagnosis. ddPCR partitions the reaction solution containing target molecules into a large number ...
Nucleic Acids Polymerase Chain Reaction Poisson Distribution Neural Networks, Computer Deep Learning
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An automated, fully-integrated nucleic acid analyzer based on microfluidic liquid handling robot technique.

Analytica chimica acta Dec 1, 2022
On-site nucleic acid testing (NAT) plays an important role for disease monitoring and pathogen diagnosis. In this work, we developed an automated and fully-integrated nucleic acid analyzer by combining the automated liquid handling robot technique wi...
Robotics Microfluidics Real-Time Polymerase Chain Reaction Nucleic Acid Amplification Techniques Nucleic Acids Humans Microfluidic Analytical Techniques
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A study on the performance and cost-effectiveness of robots in replacing manual nucleic acid collection method: Experience from the COVID-19 pandemic.

PloS one Nov 3, 2022
BACKGROUND: The COVID-19 pandemic has led nucleic acid collection and detection became a measure to ensure normal life in China. Considering the huge detection demand, it has emerged that robots replace manual sample collection. However, the cost-eff...
Robotics Pandemics Humans Nucleic Acids COVID-19 Cost-Benefit Analysis
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