AIMC Topic: Oligodendrocyte Precursor Cells

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Integrative transcriptomic analysis reveals oligodendrocyte lineage switching in multiple sclerosis.

Life science alliance Aug 4, 2025
Multiple sclerosis (MS) is a chronic disease of the central nervous system. The occurrence of MS is a phased process while its cause is still unclear. Here, by combining white matter single-nucleus transcriptomic datasets from MS and control samples,...
Humans Female Adult Animals Male Middle Aged Gene Expression Profiling Transcriptome Microglia Cell Differentiation Multiple Sclerosis White Matter Cell Lineage Oligodendrocyte Precursor Cells Oligodendroglia
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Deep learning for high-throughput quantification of oligodendrocyte ensheathment at single-cell resolution.

Communications biology Mar 26, 2019
High-throughput quantification of oligodendrocyte myelination is a challenge that, if addressed, would facilitate the development of therapeutics to promote myelin protection and repair. Here, we established a high-throughput method to assess oligode...
Brain Animals Deep Learning Single-Cell Analysis Rats Rats, Sprague-Dawley Cell Differentiation Data Accuracy Myelin Sheath Axons Nanofibers Oligodendrocyte Precursor Cells Oligodendroglia
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