Studies in health technology and informatics
Jun 6, 2022
Biomedical ontologies encode knowledge in a form that makes it computable. The current study used the integration of three large biomedical ontologies-the Disease Ontology (DO), Human Phenotype Ontology (HPO), and Radiology Gamuts Ontology (RGO)-to e...
MOTIVATION: Medical care is becoming more and more specific to patients' needs due to the increased availability of omics data. The application to these data of sophisticated machine learning models, in particular deep learning (DL), can improve the ...
Frontiers in bioscience (Landmark edition)
Mar 4, 2022
BACKGROUND: Phenotype prediction with genome-wide markers is a critical but difficult problem in biomedical research due to many issues such as nonlinearity of the underlying genetic mapping and high-dimensionality of marker data. When using the deep...
MOTIVATION: Structural genomic variants account for much of human variability and are involved in several diseases. Structural variants are complex and may affect coding regions of multiple genes, or affect the functions of genomic regions in differe...
BACKGROUND: Digital phenotyping has been proposed as a novel assessment tool for clinical trials targeting negative symptoms in psychotic disorders (PDs). However, it is unclear which digital phenotyping measurements are most appropriate for this pur...
BACKGROUND: In primary cardiovascular disease prevention, early identification of high-risk individuals is crucial. Genetic information allows for the stratification of genetic predispositions and lifetime risk of cardiovascular disease. However, tow...
Journal of neuropathology and experimental neurology
Jan 21, 2022
Alzheimer disease (AD) is a neurodegenerative disorder characterized pathologically by the presence of neurofibrillary tangles and amyloid beta (Aβ) plaques in the brain. The disease was first described in 1906 by Alois Alzheimer, and since then, the...
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2022
Cell images provide a multitude of phenotypic information, which in its entirety the human eye can hardly perceive. Automated image analysis and machine learning approaches enable the unbiased identification and analysis of cellular mechanisms and as...
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2022
Plant phenomics field has seen a great increase in scalability in the last decade mainly due to technological advances in remote sensors and phenotyping platforms. These are capable of screening thousands of plants many times throughout the day, gene...
Artificial intelligence (AI) is here to stay. It is not a future anymore, and there are many particular problems in cardiology that are already being solved via machine learning (ML), and many more are to come. AI cannot solve complex tasks yet, and ...
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