AIMC Topic: Precision Medicine

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Explainable biology for improved therapies in precision medicine: AI is not enough.

Best practice & research. Clinical rheumatology
Technological advances and high-throughput bio-chemical assays are rapidly changing ways how we formulate and test biological hypotheses, and how we treat patients. Most complex diseases arise on a background of genetics, lifestyle and environment fa...

From Biosensors to Robotics: Pioneering Advances in Breast Cancer Management.

Sensors (Basel, Switzerland)
Breast cancer stands as the most prevalent form of cancer amongst females, constituting more than one-third of all cancer cases affecting women. It causes aberrant cell development, which can assault or spread to other sections of the body, perhaps l...

Combining clinical and molecular data for personalized treatment in acute myeloid leukemia: A machine learning approach.

Computer methods and programs in biomedicine
BACKGROUND AND OBJECTIVE: The standard of care in Acute Myeloid Leukemia patients has remained essentially unchanged for nearly 40 years. Due to the complicated mutational patterns within and between individual patients and a lack of targeted agents ...

The emerging role of AI in enhancing intratumoral immunotherapy care.

Oncotarget
The emergence of immunotherapy (IO), and more recently intratumoral IO presents a novel approach to cancer treatment which can enhance immune responses while allowing combination therapy and reducing systemic adverse events. These techniques are inte...

AI-driven innovations in Alzheimer's disease: Integrating early diagnosis, personalized treatment, and prognostic modelling.

Ageing research reviews
Alzheimer's disease (AD) presents a significant challenge in neurodegenerative research and clinical practice due to its complex etiology and progressive nature. The integration of artificial intelligence (AI) into the diagnosis, treatment, and progn...

MMGCN: Multi-modal multi-view graph convolutional networks for cancer prognosis prediction.

Computer methods and programs in biomedicine
BACKGROUND AND OBJECTIVE: Accurate prognosis prediction for cancer patients plays a significant role in the formulation of treatment strategies, considerably impacting personalized medicine. Recent advancements in this field indicate that integrating...

Dose Individualisation of Antimicrobials from a Pharmacometric Standpoint: The Current Landscape.

Drugs
Successful antimicrobial therapy depends on achieving optimal drug concentrations within individual patients. Inter-patient variability in pharmacokinetics (PK) and differences in pathogen susceptibility (reflected in the minimum inhibitory concentra...

A machine-learning based model for automated recommendation of individualized treatment of rifampicin-resistant tuberculosis.

PloS one
BACKGROUND: Rifampicin resistant tuberculosis remains a global health problem with almost half a million new cases annually. In high-income countries patients empirically start a standardized treatment regimen, followed by an individualized regimen g...

Machine learning tool for predicting mature oocyte yield and trigger day from start of stimulation: towards personalized treatment.

Reproductive biomedicine online
RESEARCH QUESTION: Can machine learning tools predict the number of metaphase II (MII) oocytes and trigger day at the start of the ovarian stimulation cycle?