AIMC Topic: Protein Aggregation, Pathological

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Self-driving microscopy detects the onset of protein aggregation and enables intelligent Brillouin imaging.

Nature communications Jul 24, 2025
The process of protein aggregation, central to neurodegenerative diseases like Huntington's, is challenging to study due to its unpredictable nature and relatively rapid kinetics. Understanding its biomechanics is crucial for unraveling its role in d...
Humans Neural Networks, Computer Deep Learning Microscopy, Fluorescence Neurodegenerative Diseases Kinetics Microscopy Protein Aggregates Protein Aggregation, Pathological Protein Folding Huntington Disease
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Artificial intelligence in neurodegenerative disease research: use of IBM Watson to identify additional RNA-binding proteins altered in amyotrophic lateral sclerosis.

Acta neuropathologica Nov 13, 2017
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with no effective treatments. Numerous RNA-binding proteins (RBPs) have been shown to be altered in ALS, with mutations in 11 RBPs causing familial forms of the disease, a...
Humans Artificial Intelligence Retrospective Studies Computational Biology RNA-Binding Proteins Gene Expression Amyotrophic Lateral Sclerosis Cerebellum Data Mining Spinal Cord Protein Aggregation, Pathological Scholarly Communication
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Protective effect of Nelumbo nucifera extracts on beta amyloid protein induced apoptosis in PC12 cells, in vitro model of Alzheimer's disease.

Journal of food and drug analysis Mar 17, 2017
Alzheimer's disease (AD) is the most common cause of dementia in the elderly. β-Amyloid (Aβ) has been proposed to play a role in the pathogenesis of AD. Deposits of insoluble Aβ are found in the brains of patients with AD and are one of the pathologi...
Animals Antioxidants Plant Extracts Rats Apoptosis Reactive Oxygen Species Cell Survival Molecular Structure Amyloid beta-Peptides Chromatography, High Pressure Liquid Alzheimer Disease Protein Aggregates PC12 Cells Nelumbo Protein Aggregation, Pathological
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Assessing amyloid fibrils and amorphous aggregates: A review.

International journal of biological macromolecules Jun 1, 2025
Protein misfolding and aggregation play a central role in the progression of neurodegenerative diseases such as Alzheimer's and Parkinson's. These aggregates manifest either as structured amyloid fibrils enriched in β-sheet conformations or as irregu...
Humans Animals Amyloid Protein Aggregates Protein Aggregation, Pathological
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