AIMC Topic: Single-Domain Antibodies
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A novel nanobody and mimotope based immunoassay for rapid analysis of aflatoxin B1.
Talanta
Nov 6, 2018
Mimotopes could replace mycotoxins and their conjugates to develop immunoassay methods. The mimotopes obtained by phage display technology were mainly using monoclonal antibodies or polyclonal antibodies as targets. However, the mimotope of recombina...
Nanobody-based enzyme immunoassay for ochratoxin A in cereal with high resistance to matrix interference.
Talanta
Nov 19, 2016
A sensitive indirect competitive nanobody-based enzyme linked immunosorbent assay (Nb-ELISA) for ochratoxin A (OTA) with high resistance to cereal matrix interference was developed. Nanobodies against OTA (Nb15, Nb28, Nb32, Nb36) were expressed in E....
Development of potent humanized TNFα inhibitory nanobodies for therapeutic applications in TNFα-mediated diseases.
mAbs
Dec 1, 2025
Tumor necrosis factor-alpha (TNFα) is a key pro-inflammatory cytokine implicated in the pathogenesis of numerous inflammatory and autoimmune diseases, including rheumatoid arthritis, inflammatory bowel disease, and neurodegenerative disorders such as...
NABP-LSTM-Att: Nanobody-Antigen binding prediction using bidirectional LSTM and soft attention mechanism.
Computational biology and chemistry
Oct 1, 2025
In vertebrates, antibody-mediated immunity is a vital component of the immune system, and antibodies have become a rapidly expanding class of therapeutic agents. Nanobodies, a distinct type of antibody, have recently emerged as a stable and cost-effe...
AI-based IsAb2.0 for antibody design.
Briefings in bioinformatics
Jul 25, 2024
Therapeutic antibody design has garnered widespread attention, highlighting its interdisciplinary importance. Advancements in technology emphasize the critical role of designing nanobodies and humanized antibodies in antibody engineering. However, cu...
[Construction and identification of nanobody phage display library targeting Middle East respiratory syndrome coronavirus].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology
Dec 1, 2017
Objective To construct a phage display library of specific nano-antibodies against the Middle East respiratory syndrome coronavirus (MERS-CoV) and apply it to the screening of neutralizing nano-antibodies. Methods MERS-CoV receptor-binding domain (RB...
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