AIMC Topic: Phosphoric Diester Hydrolases

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Oral ENPP1 inhibitor designed using generative AI as next generation STING modulator for solid tumors.

Nature communications May 23, 2025
Despite the STING-type-I interferon pathway playing a key role in effective anti-tumor immunity, the therapeutic benefit of direct STING agonists appears limited. In this study, we use several artificial intelligence techniques and patient-based mult...
Humans Artificial Intelligence Female Animals Neoplasms Drug Design Cell Line, Tumor Mice Membrane Proteins Mice, Inbred C57BL Administration, Oral Phosphoric Diester Hydrolases Pyrophosphatases Nucleotides, Cyclic
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Aqueous autotaxin and TGF-βs are promising diagnostic biomarkers for distinguishing open-angle glaucoma subtypes.

Scientific reports Jan 14, 2021
The purpose of this study is to examine if aqueous autotaxin (ATX) and TGF-β levels could be used for differentiating glaucoma subtypes. This prospective observational study was performed using aqueous humor samples obtained from 281 consecutive pati...
Humans Machine Learning Prospective Studies Biomarkers Female Aged Aged, 80 and over Adult Male Middle Aged Transforming Growth Factor beta Phosphoric Diester Hydrolases Glaucoma, Open-Angle Aqueous Humor
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Variants in GNPTAB, GNPTG and NAGPA genes are associated with stutterers.

Gene Dec 28, 2017
Non-syndromic stuttering is a neurodevelopmental disorder characterized by disruptions in normal flow of speech in the form of repetition, prolongation and involuntary halts. Previously, mutations with more severe effects on GNPTAB and GNPTG have bee...
Humans Phenotype Female Male Child, Preschool Child Genetic Predisposition to Disease Mutation Heterozygote Homozygote Introns Mucolipidoses Phosphoric Diester Hydrolases Stuttering Transferases (Other Substituted Phosphate Groups)
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