AIMC Topic: Phosphocreatine

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Synthesis of higher-B CEST Z-spectra from lower-B data via deep learning and singular value decomposition.

NMR in biomedicine Aug 7, 2024
Chemical exchange saturation transfer (CEST) MRI at 3 T suffers from low specificity due to overlapping CEST effects from multiple metabolites, while higher field strengths (B) allow for better separation of Z-spectral "peaks," aiding signal interpre...
Deep Learning Rats Animals Phantoms, Imaging Phosphocreatine Rats, Sprague-Dawley Magnetic Resonance Imaging Brain
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In vivo imaging of phosphocreatine with artificial neural networks.

Nature communications Feb 26, 2020
Phosphocreatine (PCr) plays a vital role in neuron and myocyte energy homeostasis. Currently, there are no routine diagnostic tests to noninvasively map PCr distribution with clinically relevant spatial resolution and scan time. Here, we demonstrate ...
Humans Phosphocreatine Diagnostic Tests, Routine Magnetic Resonance Imaging Neural Networks, Computer Muscular Diseases Muscle, Skeletal
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Neural-network classification of cardiac disease from P cardiovascular magnetic resonance spectroscopy measures of creatine kinase energy metabolism.

Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance Aug 12, 2019
BACKGROUND: The heart's energy demand per gram of tissue is the body's highest and creatine kinase (CK) metabolism, its primary energy reserve, is compromised in common heart diseases. Here, neural-network analysis is used to test whether noninvasive...
Heart Diseases Energy Metabolism Adenosine Triphosphate Phosphorus Isotopes Phosphocreatine Magnetic Resonance Spectroscopy Neural Networks, Computer Myocardium Biomarkers Kinetics Machine Learning Creatine Kinase Severity of Illness Index Humans Predictive Value of Tests Young Adult Middle Aged Aged, 80 and over Male Adult Reproducibility of Results Female Aged
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HEPNet: A Knowledge Base Model of Human Energy Pool Network for Predicting the Energy Availability Status of an Individual.

PloS one Jun 8, 2015
HEPNet is an electronic representation of metabolic reactions occurring within human cellular organization focusing on inflow and outflow of the energy currency ATP, GTP and other energy associated moieties. The backbone of HEPNet consists of primary...
Energy Metabolism Phosphocreatine Semantics Ketoglutaric Acids Adenosine Triphosphate Glucose Computer Simulation Knowledge Bases Acyl Coenzyme A Humans Reproducibility of Results NAD Uremia Models, Biological Carnitine
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