Proceedings of the National Academy of Sciences of the United States of America
Jul 30, 2025
Past traumatic experiences shape neural responses to future stress, but the mechanisms underlying this dynamic interaction remain unclear. Here, we assessed how trauma-related brain networks respond to current acute stress in real time. Using a machi... read more
Identifying intracellular bacteria in peripheral blood smears is of utmost importance for diagnosing bacteremia in patients. However, during the initial stages, manual microscopic examination of peripheral blood smears faces significant challenges in... read more
Artificial intelligence (AI) is revolutionizing biotechnology by transforming the landscape of therapeutic development. Traditional drug discovery faces persistent challenges, including high attrition rates, billion-dollar costs, and timelines exceed... read more
Microfluidic fabrication technologies are increasingly used to produce functional anisotropic microstructures for broad applications. However, the limited flow manipulation methods hinder the production of intricate microstructure morphologies. In th... read more
OBJECTIVE: To compare clinical summaries generated from simulated patient primary care electronic health records (EHRs) by GPT-4, to summaries generated by clinicians on multiple domains of quality including utility, concision, accuracy, and bias. read more
Combination therapies enhance the therapeutic effect of cancer treatment; however, identifying effective interdependent doses, durations, and sequences of multidrug administration regimens is a time- and labor-intensive task. Here, we integrated mach... read more
The sudden arrest of flow by formation of a stable arch over an outlet is a unique and characteristic feature of granular materials. Previous work suggests that grains near the outlet randomly sample configurational flow microstates until a clog-caus... read more
Physical chemistry chemical physics : PCCP
Jul 30, 2025
The nuclear quantum effects of surface-mediated C-H activation of surface CH are considered for the pristine Pt(111) and Au(111) surfaces at 300 K. The kinetic barriers without nuclear quantum effects are calculated using both static density function... read more
The existing literature lacks a comprehensive analysis of the clinical evolution of septic patients, which is highly heterogeneous and patient-dependent. The aim of this study is to develop machine learning models capable of predicting the clinical e... read more
Physical chemistry chemical physics : PCCP
Jul 30, 2025
Acetaminophen ranks among the most widely used pharmaceutical and personal care products today. Following consumption, the drug and its metabolites are excreted into sewage systems, wastewater treatment plants, and various aquatic environments, leadi... read more
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