Journal of computer-aided molecular design
Aug 19, 2025
High failure rates in drug development are predominantly driven by suboptimal ADMET (absorption, distribution, metabolism, excretion, and toxicity) properties, with human oral bioavailability (HOB) serving as a critical determinant of therapeutic eff... read more
Water is one of the most critical and finite resources on our planet. As the demand for freshwater continues to grow, effectively managing and purifying existing water sources becomes increasingly important. This study introduces a Machine learning-b... read more
Twin research and human genetics : the official journal of the International Society for Twin Studies
Aug 19, 2025
The objective was to identify the predictive markers and develop a diagnostic model with predictive markers for Parkinson's disease (PD) and investigate the roles of immune cells in the disease pathology. Microarray datasets of PD and control samples... read more
Immunogenic cell death (ICD) is capable of activating both innate and adaptive immune responses. In this study, we aimed to develop an ICD-related signature in glioma patients and facilitate the assessment of their prognosis and drug sensitivity. Con... read more
Next-generation sequencing-based tests have advanced the field of medical diagnostics, but their novelty and cost can lead to uncertainty in clinical deployment. The Heme-STAMP is one such assay that tracks mutations in genes implicated in hematolymp... read more
BACKGROUND: Artificial intelligence (AI) technology has made significant advancements in health care. A key application of using artificial intelligence for health (AIH) is the use of AI-powered chatbots; however, empirical evidence on their effectiv... read more
BACKGROUND: Early childhood development (ECD) lays the foundation for lifelong health, academic success and social well-being, yet over 250 million children in low- and middle-income countries are at risk of not reaching their developmental potential... read more
Eye diseases can affect vision and well-being, so early, accurate diagnosis is crucial to prevent serious impairment. Deep learning models have shown promise for automating the diagnosis of eye diseases from images. However, current methods mostly us... read more
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