UNLABELLED: T-cell leukemias and lymphomas (TCL) form a heterogeneous group of rare and often aggressive malignancies. Because of the rarity and heterogeneity of TCL subtypes, clinical trials are challenging to conduct, making pharmacogenomic studies... read more
BACKGROUND AND HYPOTHESIS: Given the available findings confirming accelerated brain aging in schizophrenia (SZ), we conducted a study aimed at verifying whether quantitative retinal morphological data enable age prediction and whether schizophrenia ... read more
BACKGROUND AND HYPOTHESIS: Digital remote monitoring (DRM) captures service users' health-related data remotely using devices such as smartphones and wearables. Data can be analyzed using advanced statistical methods (eg, machine learning) and shared... read more
BACKGROUND AND HYPOTHESIS: Minor physical abnormalities (MPAs) are neurodevelopmental markers that can be traced to prenatal events and may be significant features of early-onset schizophrenia (EOS). Therefore, our study aimed to (1) find the primary... read more
BackgroundThe selection of accelerometer processing methods may influence the shape of the dose-response association between wearable-measured physical activity and health outcomes. We compared the association of stroke and myocardial infarction with... read more
Clinical trial statistical programming requires 12-24 FTE-months for a typical Phase 3 study, producing 100-500 tables, listings, and figures (TLFs) across 8-15 ADaM domains. Modern AI coding agents (Augment Code, Claude Code, Cline, Cursor) demonstr... read more
BackgroundAccurate etiologic classification of mitral valve (MV) is essential for guiding clinical management but remains dependent on expert visual interpretation. Despite advances in artificial intelligence (AI)-based quantitative analysis, automat... read more
Snakebite is a neglected public health problem that results in significant morbidity and mortality, necessitating the World Health Organization (WHO) to develop a snakebite roadmap that aimed to halve the burden of snakebite envenoming (SBE) by 2030.... read more
BackgroundCT scans are the gold-standard diagnostic test for pulmonary embolisms (PE). Despite stable PE prevalence, CT use is rising in emergency departments (EDs), suggesting test overuse. Current methods for measuring test yield are error-prone or... read more
ObjectiveHigh-frequency oscillations (HFOs) are highly specific biomarkers of epileptogenic tissue, yet their noninvasive localization remains challenging due to their brief duration, low amplitude, and poor signal-to-noise ratio. Here, we introduce ... read more
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