AI Medical Compendium Journal:
Biochemical and biophysical research communications

Showing 1 to 10 of 23 articles

Structure-based artificial intelligence-aided design of MYC-targeting degradation drugs for cancer therapy.

Biochemical and biophysical research communications
The MYC protein is an oncoprotein that plays a crucial role in various cancers. Although its significance has been well recognized in research, the development of drugs targeting MYC remains relatively slow. In this study, we developed a novel MYC pe...

A potential supplemental indication of dipyridamole for contraception: Dipyridamole inhibits mouse sperm fertilization capacity in vitro.

Biochemical and biophysical research communications
The inhibition of sperm cAMP and ATP levels, using an FDA-approved medication, may impair sperm motility and, consequently, fertilization, thus paving the way for the development of a male contraceptive. The objective of this study was to define the ...

Integrating different approaches for the identification of new disruptors of HIV-1 capsid multimerization.

Biochemical and biophysical research communications
Human Immunodeficiency Virus (HIV) belongs to the Lentivirus genus, Retroviridae family, enveloped by a lipid bilayer within which the capsid protein encases the viral genome, reverse transcriptase, and integrase proteins, key components for viral re...

Feature gene selection and functional validation of SH3KBP1 in infantile hemangioma using machine learning.

Biochemical and biophysical research communications
BACKGROUND: Infantile hemangioma (IH) is a prevalent vascular tumor in infancy with a complex pathogenesis that remains unclear. This study aimed to investigate the underlying mechanisms of IH using comprehensive bioinformatics analyses and in vitro ...

Topology-based protein classification: A deep learning approach.

Biochemical and biophysical research communications
Utilizing Artificial Intelligence (AI) in computational biology techniques could offer significant advantages in alleviating the growing workloads faced by structural biologists, especially with the emergence of big data. In this study, we employed D...

Biological computation through recurrence.

Biochemical and biophysical research communications
One of the defining features of living systems is their adaptability to changing environmental conditions. This requires organisms to extract temporal and spatial features of their environment, and use that information to compute the appropriate resp...

Shaping dynamical neural computations using spatiotemporal constraints.

Biochemical and biophysical research communications
Dynamics play a critical role in computation. The principled evolution of states over time enables both biological and artificial networks to represent and integrate information to make decisions. In the past few decades, significant multidisciplinar...

A machine learning based method for tracking of simultaneously imaged neural activity and body posture of freely moving maggot.

Biochemical and biophysical research communications
To understand neural basis of animal behavior, it is necessary to monitor neural activity and behavior in freely moving animal before building relationship between them. Here we use light sheet fluorescence microscope (LSFM) combined with microfluidi...

Machine learning and related approaches in transcriptomics.

Biochemical and biophysical research communications
Data acquisition for transcriptomic studies used to be the bottleneck in the transcriptomic analytical pipeline. However, recent developments in transcriptome profiling technologies have increased researchers' ability to obtain data, resulting in a s...

Living cells and biological mechanisms as prototypes for developing chemical artificial intelligence.

Biochemical and biophysical research communications
Artificial Intelligence (AI) is having a revolutionary impact on our societies. It is helping humans in facing the global challenges of this century. Traditionally, AI is developed in software or through neuromorphic engineering in hardware. More rec...