SIGNIFICANCE: Treatment planning for light-based therapies including photodynamic therapy requires tissue optical property knowledge. This is recoverable with spatially resolved diffuse reflectance spectroscopy (DRS) but requires precise source-detec...
SIGNIFICANCE: Artificial intelligence (AI) has become a prominent technology in computational imaging over the past decade. The expeditious and label-free characteristics of quantitative phase imaging (QPI) render it a promising contender for AI inve...
SIGNIFICANCE: Diffuse correlation spectroscopy (DCS) is a powerful, noninvasive optical technique for measuring blood flow. Traditionally the blood flow index (BFi) is derived through nonlinear least-square fitting the measured intensity autocorrelat...
SIGNIFICANCE: Machine learning (ML)-enabled diffuse reflectance spectroscopy (DRS) is increasingly used as an alternative to the computation-intensive inverse Monte Carlo (MCI) simulation to predict tissue's optical properties, including the absorpti...
SIGNIFICANCE: Label-free, two-photon excited fluorescence (TPEF) imaging captures morphological and functional metabolic tissue changes and enables enhanced understanding of numerous diseases. However, noise and other artifacts present in these image...
SIGNIFICANCE: Current treatment for stage III colorectal cancer (CRC) patients involves surgery that may not be sufficient in many cases, requiring additional adjuvant systemic therapy. Identification of this latter cohort that is likely to recur fol...
SIGNIFICANCE: Interventional cardiac procedures often require ionizing radiation to guide cardiac catheters to the heart. To reduce the associated risks of ionizing radiation, photoacoustic imaging can potentially be combined with robotic visual serv...
SIGNIFICANCE: Mueller matrix (MM) microscopy has proven to be a powerful tool for probing microstructural characteristics of biological samples down to subwavelength scale. However, in clinical practice, doctors usually rely on bright-field microscop...
SIGNIFICANCE: Ultrasound (US)-guided diffuse optical tomography (DOT) has demonstrated great potential for breast cancer diagnosis in which real-time or near real-time diagnosis with high accuracy is desired.
SIGNIFICANCE: Diabetes is a prevalent disease worldwide that can cause severe health problems. Accurate blood glucose detection is crucial for diabetes management, and noninvasive methods can be more convenient and less painful than traditional finge...