AI Medical Compendium Journal:
PLoS computational biology

Showing 41 to 50 of 484 articles

Deep neural networks for endemic measles dynamics: Comparative analysis and integration with mechanistic models.

PLoS computational biology
Measles is an important infectious disease system both for its burden on public health and as an opportunity for studying nonlinear spatio-temporal disease dynamics. Traditional mechanistic models often struggle to fully capture the complex nonlinear...

Learning patterns of HIV-1 resistance to broadly neutralizing antibodies with reduced subtype bias using multi-task learning.

PLoS computational biology
The ability to predict HIV-1 resistance to broadly neutralizing antibodies (bnAbs) will increase bnAb therapeutic benefits. Machine learning is a powerful approach for such prediction. One challenge is that some HIV-1 subtypes in currently available ...

Rapid prediction of key residues for foldability by machine learning model enables the design of highly functional libraries with hyperstable constrained peptide scaffolds.

PLoS computational biology
Peptides are an emerging modality for developing therapeutics that can either agonize or antagonize cellular pathways associated with disease, yet peptides often suffer from poor chemical and physical stability, which limits their potential. However,...

Simplified internal models in human control of complex objects.

PLoS computational biology
Humans are skillful at manipulating objects that possess nonlinear underactuated dynamics, such as clothes or containers filled with liquids. Several studies suggested that humans implement a predictive model-based strategy to control such objects. H...

Human-like dissociations between confidence and accuracy in convolutional neural networks.

PLoS computational biology
Prior research has shown that manipulating stimulus energy by changing both stimulus contrast and variability results in confidence-accuracy dissociations in humans. Specifically, even when performance is matched, higher stimulus energy leads to high...

Deep-learning models reveal how context and listener attention shape electrophysiological correlates of speech-to-language transformation.

PLoS computational biology
To transform continuous speech into words, the human brain must resolve variability across utterances in intonation, speech rate, volume, accents and so on. A promising approach to explaining this process has been to model electroencephalogram (EEG) ...

Teaching deep networks to see shape: Lessons from a simplified visual world.

PLoS computational biology
Deep neural networks have been remarkably successful as models of the primate visual system. One crucial problem is that they fail to account for the strong shape-dependence of primate vision. Whereas humans base their judgements of category membersh...

A deep learning model for prediction of autism status using whole-exome sequencing data.

PLoS computational biology
Autism is a developmental disability. Research demonstrated that children with autism benefit from early diagnosis and early intervention. Genetic factors are considered major contributors to the development of autism. Machine learning (ML), includin...

During haptic communication, the central nervous system compensates distinctly for delay and noise.

PLoS computational biology
Physically connected humans have been shown to exploit the exchange of haptic forces and tactile information to improve their performance in joint action tasks. As human interactions are increasingly mediated through robots and networks it is importa...

Managing spatio-temporal heterogeneity of susceptibles by embedding it into an homogeneous model: A mechanistic and deep learning study.

PLoS computational biology
Accurate prediction of epidemics is pivotal for making well-informed decisions for the control of infectious diseases, but addressing heterogeneity in the system poses a challenge. In this study, we propose a novel modelling framework integrating the...