AIMC Topic: Adjuvants, Immunologic

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Safety, tolerability, pharmacokinetics, and pharmacodynamics of oral JNJ-64794964, a TLR-7 agonist, in healthy adults.

Antiviral therapy Oct 27, 2021
BACKGROUND: This Phase I, two-part, first-in-human study assessed safety/tolerability and pharmacokinetics/pharmacodynamics of single-ascending doses (SAD) and multiple doses (MD) of the oral toll-like receptor-7 agonist, JNJ-64794964 (JNJ-4964) in h...
Humans Cytokines Adult Area Under Curve Double-Blind Method Adjuvants, Immunologic Interferon-alpha Toll-Like Receptor 7
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Identification of Immune Signatures of Novel Adjuvant Formulations Using Machine Learning.

Scientific reports Nov 30, 2018
Adjuvants have long been critical components of vaccines, but the exact mechanisms of their action and precisely how they alter or enhance vaccine-induced immune responses are often unclear. In this study, we used broad immunoprofiling of antibody, c...
Machine Learning Cytokines Animals Immunity, Cellular CD8-Positive T-Lymphocytes CD4-Positive T-Lymphocytes Adjuvants, Immunologic Vaccines Liposomes Dose-Response Relationship, Immunologic Macaca mulatta
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Broadly active intranasal influenza vaccine with a nanocomplex particulate adjuvant targeting mast cells and toll-like receptor 9.

Journal of controlled release : official journal of the Controlled Release Society Aug 10, 2025
Flumist is the only FDA-approved intranasal influenza vaccine. Although it has recently been approved for at-home use, it has significant limitations. These include reduced effectiveness in generating a protective immune response in patients with ext...
Humans Female Animals Mice Nanoparticles Mice, Inbred BALB C Mast Cells Adjuvants, Immunologic Influenza Vaccines Orthomyxoviridae Infections Administration, Intranasal Oligodeoxyribonucleotides Hemagglutinin Glycoproteins, Influenza Virus Toll-Like Receptor 9
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Application of in-silico approaches in subunit vaccines: Overcoming the challenges of antigen and adjuvant development.

Journal of controlled release : official journal of the Controlled Release Society May 10, 2025
Subunit vaccines are crucial in preventing modern diseases due to their safety, stability, and ability to elicit targeted immune responses. However, challenges in antigen and adjuvant design hinder their development. Recent advancements in in-silico ...
Humans Machine Learning Computer Simulation Animals Vaccine Development Adjuvants, Immunologic Antigens Vaccines, Subunit Vaccinology
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