AIMC Topic: Animal Testing Alternatives
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A mode-of-action ontology model for safety evaluation of chemicals: Outcome of a series of workshops on repeated dose toxicity.
Toxicology in vitro : an international journal published in association with BIBRA
Apr 4, 2019
Repeated dose toxicity evaluation aims at assessing the occurrence of adverse effects following chronic or repeated exposure to chemicals. Non-animal approaches have gained importance in the last decades because of ethical considerations as well as d...
Transfer learning for predicting human skin sensitizers.
Archives of toxicology
Feb 26, 2019
Computational prioritization of chemicals for potential skin sensitization risks plays essential roles in the risk assessment of environmental chemicals and drug development. Given the huge number of chemicals for testing, computational methods enabl...
An evaluation of selected (Q)SARs/expert systems for predicting skin sensitisation potential.
SAR and QSAR in environmental research
Apr 20, 2018
Predictive testing to characterise substances for their skin sensitisation potential has historically been based on animal models such as the Local Lymph Node Assay (LLNA) and the Guinea Pig Maximisation Test (GPMT). In recent years, EU regulations, ...
Design and validation of an ontology-driven animal-free testing strategy for developmental neurotoxicity testing.
Toxicology and applied pharmacology
Mar 13, 2018
Developmental neurotoxicity entails one of the most complex areas in toxicology. Animal studies provide only limited information as to human relevance. A multitude of alternative models have been developed over the years, providing insights into mech...
Toward a systematic exploration of nano-bio interactions.
Toxicology and applied pharmacology
Mar 24, 2017
Many studies of nanomaterials make non-systematic alterations of nanoparticle physicochemical properties. Given the immense size of the property space for nanomaterials, such approaches are not very useful in elucidating fundamental relationships bet...
Prediction of skin sensitization potency using machine learning approaches.
Journal of applied toxicology : JAT
Jan 10, 2017
The replacement of animal use in testing for regulatory classification of skin sensitizers is a priority for US federal agencies that use data from such testing. Machine learning models that classify substances as sensitizers or non-sensitizers witho...
Probabilistic hazard assessment for skin sensitization potency by dose-response modeling using feature elimination instead of quantitative structure-activity relationships.
Journal of applied toxicology : JAT
Jun 5, 2015
Supervised learning methods promise to improve integrated testing strategies (ITS), but must be adjusted to handle high dimensionality and dose-response data. ITS approaches are currently fueled by the increasing mechanistic understanding of adverse ...
An in silico expert system for the identification of eye irritants.
SAR and QSAR in environmental research
May 13, 2015
This report describes development of an in silico, expert rule-based method for the classification of chemicals into irritants or non-irritants to eye, as defined by the Draize test. This method was developed to screen data-poor cosmetic ingredient c...
The potential of AOP networks for reproductive and developmental toxicity assay development.
Reproductive toxicology (Elmsford, N.Y.)
Apr 15, 2015
Historically, the prediction of reproductive and developmental toxicity has largely relied on the use of animals. The adverse outcome pathway (AOP) framework forms a basis for the development of new non-animal test methods. It also provides biologica...
Fetal Development
Gene Expression Regulation, Developmental
Embryonic Development
Toxicity Tests
Animal Testing Alternatives
Systems Integration
Models, Biological
Knowledge Bases
Reproduction
Animals
Humans
Risk Assessment
Gene Regulatory Networks
Signal Transduction
Computer Simulation
Pregnancy
Female
Evaluation of combinations of in vitro sensitization test descriptors for the artificial neural network-based risk assessment model of skin sensitization.
Journal of applied toxicology : JAT
Mar 30, 2015
The skin sensitization potential of chemicals has been determined with the use of the murine local lymph node assay (LLNA). However, in recent years public concern about animal welfare has led to a requirement for non-animal risk assessment systems f...
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