AIMC Topic: Animals
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Harnessing artificial intelligence to identify Bufalin as a molecular glue degrader of estrogen receptor alpha.
Nature communications
Aug 22, 2025
Target identification in natural products plays a critical role in the development of innovative drugs. Bufalin, a compound derived from traditional medicines, has shown promising anti-cancer activity; however, its precise molecular mechanism of acti...
Human iPSC-derived spinal neural progenitors enhance sensorimotor recovery in spinal cord-injured NOD-SCID mice via differentiation and microenvironment regulation.
Cell death & disease
Aug 22, 2025
Spinal cord injury (SCI) remains a significant clinical challenge and poses a dramatic threat to the life quality of patients due to limited neural regeneration and detrimental post-injury alternations in tissue microenvironment. We developed a thera...
Image-based honey bee larval viral and bacterial diagnosis using machine learning.
Scientific reports
Aug 21, 2025
Honey bees are essential pollinators of ecosystems and agriculture worldwide. With an estimated 50-80% of crops pollinated by honey bees, they generate approximately $20 billion annually in market value in the U.S. alone. However, commercial beekeepe...
Integrating artificial intelligence and optogenetics for Parkinson's disease diagnosis and therapeutics in male mice.
Nature communications
Aug 21, 2025
Parkinson's disease (PD), a progressive neurodegenerative disorder, presents complex motor symptoms and lacks effective disease-modifying treatments. Here we show that integrating artificial intelligence (AI) with optogenetic intervention, termed opt...
Systematic selection of best performing mathematical models for in vitro gas production using machine learning across diverse feeds.
Scientific reports
Aug 21, 2025
In vitro gas production (GP) is commonly used to evaluate ruminant feed, yet its accurate interpretation requires robust mathematical modeling. This study systematically explores a wide array of nonlinear models to explain GP dynamics across various ...
Balancing ethics and statistics: machine learning facilitates highly accurate classification of mice according to their trait anxiety with reduced sample sizes.
Translational psychiatry
Aug 21, 2025
Understanding how individual differences influence vulnerability to disease and responses to pharmacological treatments represents one of the main challenges in behavioral neuroscience. Nevertheless, inter-individual variability and sex-specific patt...
Ultrafast elastocapillary fans control agile maneuvering in ripple bugs and robots.
Science (New York, N.Y.)
Aug 21, 2025
ripple bugs use specialized middle-leg fans with a flat-ribbon architecture to navigate the surfaces of fast-moving streams. We show that the fan's directional stiffness enables fast, passive elastocapillary morphing, independent of muscle input. Th...
Machine learning-assisted MALDI-MSI to characterize hippocampal subregion lipid and purine metabolic alterations in depression-related dry eye disease.
Analytical methods : advancing methods and applications
Aug 21, 2025
Dry eye disease (DED) and depression exhibit high comorbidity, yet lipid and purine diagnostic biomarkers for depression-related DED remain unidentified. In this study, matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI)...
BlueGuppy: tunable kinematics enables maneuverability in a minimalist fish-like robot.
Bioinspiration & biomimetics
Aug 21, 2025
Aquatic ecosystems vital to biodiversity and climate change-such as coral reefs, kelp forests, and mangrove forests-are often cluttered with natural obstacles. To navigate these complex habitats, fish have evolved relatively small body sizes and outs...
Eyes in the sky: Drone monitoring of the largest gharial and mugger populations in the East Rapti River, Chitwan National Park.
PloS one
Aug 21, 2025
Drone-based aerial monitoring can play a pivotal role in scaling up efforts to monitor species at risk. In this study, we assessed the population size, occupancy, and spatial interactions of gharials and muggers in the Eastern Rapti River and its tri...
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