AIMC Topic: Locus Coeruleus
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Brainstem noradrenergic modulation of the kisspeptin neuron GnRH pulse generator in mice.
Nature communications
Jul 1, 2025
Brainstem noradrenaline (NA) neurons modulate the activity of many neural networks including those responsible for the control of fertility. Using brain slice electrophysiology, we demonstrate that the arcuate nucleus kisspeptin (ARN) neurons, recent...
Fully automated deep learning-based localization and segmentation of the locus coeruleus in aging and Parkinson's disease using neuromelanin-sensitive MRI.
International journal of computer assisted radiology and surgery
Nov 19, 2021
PURPOSE: Development and performance measurement of a fully automated pipeline that localizes and segments the locus coeruleus in so-called neuromelanin-sensitive magnetic resonance imaging data for the derivation of quantitative biomarkers of neurod...
Automated Mouse Pupil Size Measurement System to Assess Locus Coeruleus Activity with a Deep Learning-Based Approach.
Sensors (Basel, Switzerland)
Oct 26, 2021
Strong evidence from studies on primates and rodents shows that changes in pupil diameter may reflect neural activity in the locus coeruleus (LC). Pupillometry is the only available non-invasive technique that could be used as a reliable and easily a...
Sub-millimeter variation in human locus coeruleus is associated with dimensional measures of psychopathology: An in vivo ultra-high field 7-Tesla MRI study.
NeuroImage. Clinical
Jan 15, 2020
The locus coeruleus (LC) has a long-established role in the attentional and arousal response to threat, and in the emergence of pathological anxiety in pre-clinical models. However, human evidence of links between LC function and pathological anxiety...
A connectionist modeling study of the neural mechanisms underlying pain's ability to reorient attention.
Cognitive, affective & behavioral neuroscience
Aug 1, 2016
Connectionist modeling was used to investigate the brain mechanisms responsible for pain's ability to shift attention away from another stimulus modality and toward itself. Different connectionist model architectures were used to simulate the differe...
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