AIMC Topic: Aortic Valve Disease

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Machine learning and multi-omics integration reveal TRPV2 as a central regulator in bicuspid aortic valve calcification.

Biochemical and biophysical research communications Oct 21, 2025
BACKGROUND: Bicuspid aortic valve (BAV), the most common congenital heart defect, is strongly predisposed to early calcification, yet the molecular drivers remain poorly defined. This study aims to identify the functional role of transient receptor p...
Humans Machine Learning Animals Gene Expression Profiling TRPV Cation Channels Gene Regulatory Networks Mice Multiomics Calcinosis Aortic Valve Stenosis Aortic Valve MicroRNAs RNA, Long Noncoding Osteogenesis Bicuspid Aortic Valve Disease Heart Valve Diseases Calcium Channels Aortic Valve Disease
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Network-based screen in iPSC-derived cells reveals therapeutic candidate for heart valve disease.

Science (New York, N.Y.) Dec 10, 2020
Mapping the gene-regulatory networks dysregulated in human disease would allow the design of network-correcting therapies that treat the core disease mechanism. However, small molecules are traditionally screened for their effects on one to several o...
Humans Machine Learning Algorithms Animals Drug Discovery RNA-Seq Gene Regulatory Networks Mice Disease Models, Animal Mice, Inbred C57BL Calcinosis Aortic Valve Stenosis Aortic Valve Drug Evaluation, Preclinical Thiazoles Gene Expression Regulation Nitriles Small Molecule Libraries Induced Pluripotent Stem Cells Receptor, Notch1 Haploinsufficiency Aortic Valve Disease
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