AIMC Topic: Aortic Valve Disease

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Network-based screen in iPSC-derived cells reveals therapeutic candidate for heart valve disease.

Science (New York, N.Y.) Dec 10, 2020
Mapping the gene-regulatory networks dysregulated in human disease would allow the design of network-correcting therapies that treat the core disease mechanism. However, small molecules are traditionally screened for their effects on one to several o...
Humans Machine Learning Algorithms Animals Drug Discovery RNA-Seq Gene Regulatory Networks Mice Disease Models, Animal Mice, Inbred C57BL Calcinosis Aortic Valve Stenosis Aortic Valve Drug Evaluation, Preclinical Thiazoles Gene Expression Regulation Nitriles Small Molecule Libraries Induced Pluripotent Stem Cells Receptor, Notch1 Haploinsufficiency Aortic Valve Disease
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