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Aortic Valve Disease

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Network-based screen in iPSC-derived cells reveals therapeutic candidate for heart valve disease.

Science (New York, N.Y.) 33303684
Mapping the gene-regulatory networks dysregulated in human disease would allow the design of network-correcting therapies that treat the core disease mechanism. However, small molecules are traditionally screened for their effects on one to several o...
Algorithms Animals Aortic Valve Aortic Valve Disease Aortic Valve Stenosis Calcinosis Disease Models, Animal Drug Discovery Drug Evaluation, Preclinical Gene Expression Regulation Gene Regulatory Networks Haploinsufficiency Humans Induced Pluripotent Stem Cells Machine Learning Mice Mice, Inbred C57BL Nitriles Receptor, Notch1 RNA-Seq Small Molecule Libraries Thiazoles
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