AIMC Topic: Calcium Channels
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Impact of sub and supra-threshold adaptation currents in networks of spiking neurons.
Journal of computational neuroscience
Sep 24, 2015
Neuronal adaptation is the intrinsic capacity of the brain to change, by various mechanisms, its dynamical responses as a function of the context. Such a phenomena, widely observed in vivo and in vitro, is known to be crucial in homeostatic regulatio...
AI-Driven Drug Target Screening Platform Identified Oncogene CACNA2D1 Activated by Enhancer Infestation in Epstein-Barr Virus-Associated Nasopharyngeal Carcinoma.
International journal of molecular sciences
May 14, 2025
The management of nasopharyngeal cancer (NPC) is rapidly evolving, with immune checkpoint inhibitors emerging as a prominent treatment approach. However, drug development targeting specific molecular and cellular abnormalities in NPC has slowed. Rece...
Ex-vivo antihypertensive and calcium channel blocking activity of Androsace foliosa n-hexane leaves fraction on isolated rabbit aorta.
Pakistan journal of pharmaceutical sciences
Nov 1, 2019
Hypertension is persistent elevation in blood pressure for 3-4 weeks. Estimated global prevalence of hypertension suggested that by the Year 2025 (29%) of adult worldwide are suffering from hypertension (1.56 billion). Hypertension complications are ...
Spasmolytic activity of Aquilariae Lignum Resinatum extract on gastrointestinal motility involves muscarinic receptors, calcium channels and NO release.
Pharmaceutical biology
Dec 1, 2018
CONTEXT: Aquilariae Lignum Resinatum (ALR), the dry rhizome of Aquilaria agallocha R. (Thymelaeaeeae), has been widely used to treat emesis, stomachache and gastrointestinal dysfunction.
Synaptic Mechanisms of Memory Consolidation during Sleep Slow Oscillations.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Apr 13, 2016
UNLABELLED: Sleep is critical for regulation of synaptic efficacy, memories, and learning. However, the underlying mechanisms of how sleep rhythms contribute to consolidating memories acquired during wakefulness remain unclear. Here we studied the ro...
Mutation analysis of 6 spinocerebellar ataxia (SCA) types in patients from southern Turkey.
Turkish journal of medical sciences
Jan 1, 2015
BACKGROUND/AIM: Spinocerebellar ataxias (SCAs) are complex clinical and genetically heterogeneous, mostly autosomal dominant neurodegenerative diseases. At present, more than 30 hereditary SCA types have been associated with different gene mutations....
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