AIMC Topic: Receptor, Notch1

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Screening core genes for minimal change disease based on bioinformatics and machine learning approaches.

International urology and nephrology Oct 9, 2024
Based on bioinformatics and machine learning methods, we conducted a study to screen the core genes of minimal change disease (MCD) and further explore its pathogenesis. First, we obtained the chip data sets GSE108113 and GSE200828 from the Gene Expr...
Machine Learning Computational Biology Humans Tumor Suppressor Protein p53 Receptor, Notch1 Nephrosis, Lipoid Transforming Growth Factor beta1
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Network-based screen in iPSC-derived cells reveals therapeutic candidate for heart valve disease.

Science (New York, N.Y.) Dec 10, 2020
Mapping the gene-regulatory networks dysregulated in human disease would allow the design of network-correcting therapies that treat the core disease mechanism. However, small molecules are traditionally screened for their effects on one to several o...
Receptor, Notch1 Induced Pluripotent Stem Cells Aortic Valve Disease Haploinsufficiency Gene Expression Regulation Nitriles RNA-Seq Humans Small Molecule Libraries Drug Discovery Algorithms Animals Mice Aortic Valve Machine Learning Mice, Inbred C57BL Gene Regulatory Networks Disease Models, Animal Aortic Valve Stenosis Calcinosis Drug Evaluation, Preclinical Thiazoles
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Node-based differential network analysis in genomics.

Computational biology and chemistry Apr 4, 2017
Gene dependency networks often undergo changes in response to different conditions. Understanding how these networks change across two conditions is an important task in genomics research. Most previous differential network analysis approaches assume...
Insulin Receptor Substrate Proteins Proto-Oncogene Proteins c-kit Ovarian Neoplasms Shc Signaling Adaptor Proteins Receptor, Notch1 Humans 3-Phosphoinositide-Dependent Protein Kinases Machine Learning Breast Neoplasms Female Gene Regulatory Networks Genomics
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Calcific aortic valve disease: turning therapeutic discovery up a notch.

Nature reviews. Cardiology May 1, 2021
Machine Learning Gene Regulatory Networks Humans Aortic Valve Thiazoles Aortic Valve Stenosis Calcinosis Induced Pluripotent Stem Cells Cardiovascular Agents ERRalpha Estrogen-Related Receptor Receptor, Notch1 Endothelial Cells Receptors, Estrogen Nitriles
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