AIMC Topic: Biocatalysis
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Bio-transformation of green tea infusion with tannase and its improvement on adipocyte metabolism.
Enzyme and microbial technology
Dec 23, 2019
Catechins in green tea possess various health benefits. Enzymatic treatment improves physiological activities by inducing bioconversion of catechins. Here, we investigated the effect of green tea infusion (GT) after tannase treatment, which transform...
Construction of arming Yarrowia lipolytica surface-displaying soybean seed coat peroxidase for use as whole-cell biocatalyst.
Enzyme and microbial technology
Dec 20, 2019
Whole-cell biocatalysts could be used in wide-ranging applications. In this study, a new kind of whole-cell biocatalyst was successfully constructed by genetically immobilizing soybean seed coat peroxidase (SBP) on the cell surface of Yarrowia lipoly...
Machine Learning Identifies Chemical Characteristics That Promote Enzyme Catalysis.
Journal of the American Chemical Society
Feb 21, 2019
Despite tremendous progress in understanding and engineering enzymes, knowledge of how enzyme structures and their dynamics induce observed catalytic properties is incomplete, and capabilities to engineer enzymes fall far short of industrial needs. H...
Unlocking the hidden talent of DNA: Unexpected catalytic activity for colorimetric assay of alkaline phosphatase.
Analytica chimica acta
Dec 21, 2018
Carboxylic acids have been efficiently used to activate HO to form even more potent oxidant-peroxy acids through enzyme-catalyzed processes. By employing acetic acid as the activator, herein we report for the first time that cofactor-free DNA display...
Machine learning applied to enzyme turnover numbers reveals protein structural correlates and improves metabolic models.
Nature communications
Dec 7, 2018
Knowing the catalytic turnover numbers of enzymes is essential for understanding the growth rate, proteome composition, and physiology of organisms, but experimental data on enzyme turnover numbers is sparse and noisy. Here, we demonstrate that machi...
Optimization and modelling of enzymatic polymerization of ε-caprolactone to polycaprolactone using Candida Antartica Lipase B with response surface methodology and artificial neural network.
Enzyme and microbial technology
Dec 5, 2018
Recently enzymatic catalysts have replaced organic and organometallic catalysts in the synthesis of bio-resorbable polymers. Enzymatic polymerization is considered as an alternative to conventional polymerization as they are less toxic, environmental...
Multiclassification Prediction of Enzymatic Reactions for Oxidoreductases and Hydrolases Using Reaction Fingerprints and Machine Learning Methods.
Journal of chemical information and modeling
May 21, 2018
Drug metabolism is a complex procedure in the human body, including a series of enzymatically catalyzed reactions. However, it is costly and time consuming to investigate drug metabolism experimentally; computational methods are hence developed to pr...
Ultrasound-assisted d-tartaric acid whole-cell bioconversion by recombinant Escherichia coli.
Ultrasonics sonochemistry
Nov 2, 2017
d-Tartaric acid has wide range of application in the pharmaceutical industry and scarcely exists in nature. In this study, cis-epoxysuccinate hydrolase (CESH)-containing Escherichia coli was used to perform whole-cell bioconversion of cis-epoxysuccin...
Manipulation of Biomolecule-Modified Liquid-Metal Blobs.
Angewandte Chemie (International ed. in English)
Oct 2, 2017
Soft and deformable liquid metals (LMs) are building components in various systems related to uncertain and dynamic task environments. Herein we describe the development of a biomolecule-triggered external-manipulation method involving LM conjugates ...
modeling of the cryptic E2∼ubiquitin-binding site of E6-associated protein (E6AP)/UBE3A reveals the mechanism of polyubiquitin chain assembly.
The Journal of biological chemistry
Sep 18, 2017
To understand the mechanism for assembly of Lys-linked polyubiquitin degradation signals, we previously demonstrated that the E6AP/UBE3A ligase harbors two functionally distinct E2∼ubiquitin-binding sites: a high-affinity Site 1 required for E6AP Cys...
Humans
Animals
Cysteine
Protein Multimerization
Ubiquitin-Protein Ligases
Iodine Radioisotopes
Isoenzymes
Amino Acid Substitution
Binding Sites
Expert Systems
Point Mutation
Molecular Docking Simulation
Recombinant Fusion Proteins
Mutagenesis, Site-Directed
Biocatalysis
Ubiquitin-Conjugating Enzymes
Cattle
Ubiquitin
Protein Conformation
Computational Biology
Ubiquitination
Models, Molecular
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