AIMC Topic: Blood-Brain Barrier
Clear Filters Showing 51 to 60 of 73 articles
Cognitively impaired elderly exhibit insulin resistance and no memory improvement with infused insulin.
Neurobiology of aging
Dec 1, 2015
Insulin resistance is a risk factor for Alzheimer's disease (AD), although its role in AD etiology is unclear. We assessed insulin resistance using fasting and insulin-stimulated measures in 51 elderly subjects with no dementia (ND; n = 37) and with ...
A method to predict different mechanisms for blood-brain barrier permeability of CNS activity compounds in Chinese herbs using support vector machine.
Journal of bioinformatics and computational biology
Oct 27, 2015
The blood-brain barrier (BBB), a highly selective barrier between central nervous system (CNS) and the blood stream, restricts and regulates the penetration of compounds from the blood into the brain. Drugs that affect the CNS interact with the BBB p...
Drug Evaluation, Preclinical
Central Nervous System Agents
Permeability
Plants, Medicinal
Molecular Targeted Therapy
Support Vector Machine
Medicine, Chinese Traditional
ATP Binding Cassette Transporter, Subfamily B, Member 1
Reproducibility of Results
Blood-Brain Barrier
Models, Theoretical
Humans
Algorithms
A Genetic Algorithm Based Support Vector Machine Model for Blood-Brain Barrier Penetration Prediction.
BioMed research international
Oct 4, 2015
Blood-brain barrier (BBB) is a highly complex physical barrier determining what substances are allowed to enter the brain. Support vector machine (SVM) is a kernel-based machine learning method that is widely used in QSAR study. For a successful SVM ...
3BTRON: A Blood-Brain Barrier Recognition Network.
Communications biology
Jul 4, 2025
The blood-brain barrier (BBB) plays a crucial role in maintaining brain homeostasis. During ageing, the BBB undergoes structural alterations. Electron microscopy (EM) is the gold standard for studying the structural alterations of the brain vasculatu...
Interpretable Multimodal Deep Ensemble Framework Dissecting Bloodbrain Barrier Permeability with Molecular Features.
The journal of physical chemistry letters
Jun 12, 2025
Blood-brain barrier permeability (BBBP) prediction plays a critical role in the drug discovery process, particularly for compounds targeting the central nervous system. While machine learning (ML) has significantly advanced the prediction of BBBP, th...
A novel in silico approach for predicting unbound brain-to-plasma ratio using machine learning-based support vector regression.
Computers in biology and medicine
Jun 1, 2025
The blood-brain barrier (BBB) functions as a vital protective mechanism, restricting the entry of substances and xenobiotics into the central nervous system (CNS). Consequently, BBB penetration is a critical aspect of absorption, distribution, metabo...
Predicting the Brain-To-Plasma Unbound Partition Coefficient of Compounds via Formula-Guided Network.
Journal of chemical information and modeling
May 26, 2025
Blood-brain barrier (BBB) permeability plays a crucial role in determining drug efficacy in the brain, with the brain-to-plasma unbound partition coefficient () recognized as a key parameter of BBB permeability in drug development. However, data are...
Lipid nanoparticle (LNP) mediated mRNA delivery in neurodegenerative diseases.
Journal of controlled release : official journal of the Controlled Release Society
May 10, 2025
Neurodegenerative diseases (NDD) are characterized by the progressive loss of neurons and the impairment of cellular functions. Messenger RNA (mRNA) has emerged as a promising therapy for treating NDD, as it can encode missing or dysfunctional protei...
Blood-brain barrier crossing biopolymer targeting c-Myc and anti-PD-1 activate primary brain lymphoma immunity: Artificial intelligence analysis.
Journal of controlled release : official journal of the Controlled Release Society
May 10, 2025
Primary Central Nervous System Lymphoma is an aggressive central nervous system neoplasm with poor response to pharmacological treatment, partially due to insufficient drug delivery across blood-brain barrier. In this study, we developed a novel ther...
Unsupervised Deep Learning for Blood-Brain Barrier Leakage Detection in Diffuse Glioma Using Dynamic Contrast-enhanced MRI.
Radiology. Artificial intelligence
May 1, 2025
Purpose To develop an unsupervised deep learning framework for generalizable blood-brain barrier leakage detection using dynamic contrast-enhanced MRI, without requiring pharmacokinetic models and arterial input function estimation. Materials and Met...
Don't Miss the Future of Medicine
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.
Subscribe NowPopular Topics
- Machine Learning 30978
- Neural Networks, Computer 29696
- Algorithms 26813
- Deep Learning 26324
- Artificial Intelligence 24267
- Robotics 13307
- Image Processing, Computer-Assisted 9512
- Retrospective Studies 9097
- Magnetic Resonance Imaging 6173
- Reproducibility of Results 5589
- Tomography, X-Ray Computed 4765
- Support Vector Machine 4678
- Computational Biology 4229
- Brain 4045
- Computer Simulation 3877
Recent Journals
- Scientific reports 5865
- Sensors (Basel, Switzerland) 4794
- PloS one 4011
- Neural networks : the official journal of the International Neural Network Society 2928
- Computational intelligence and neuroscience 1931
- Computers in biology and medicine 1839
- Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 1686
- Studies in health technology and informatics 1278
- IEEE journal of biomedical and health informatics 1129
- Journal of chemical information and modeling 994
- Nature communications 938
- Computer methods and programs in biomedicine 883
- Bioinformatics (Oxford, England) 861
- Briefings in bioinformatics 850
- IEEE transactions on neural networks and learning systems 823