An important model system for understanding genes, neurons and behavior, the nematode worm C. elegans naturally moves through a variety of complex postures, for which estimation from video data is challenging. We introduce an open-source Python packa...
To enable large-scale analyses of transcription regulation in model species, we developed DeepArk, a set of deep learning models of the -regulatory activities for four widely studied species: , , , and DeepArk accurately predicts the presence of tho...
International journal of molecular sciences
34064595
Experimental studies of and have contributed substantially to our understanding of molecular and cellular processes in metazoans at large. Since the publication of their genomes, functional genomic investigations have identified genes that are esse...
Learning from the locomotion of natural organisms is one of the most effective strategies for designing microrobots. However, the development of bioinspired microrobots is still challenging because of technical bottlenecks such as design and seamless...
In systemic light chain amyloidosis (AL), pathogenic monoclonal immunoglobulin light chains (LC) form toxic aggregates and amyloid fibrils in target organs. Prompt diagnosis is crucial to avoid permanent organ damage, but delayed diagnosis is common ...
The automation of lifespan assays with in standard Petri dishes is a challenging problem because there are several problems hindering detection such as occlusions at the plate edges, dirt accumulation, and worm aggregations. Moreover, determining wh...
Two recent studies published in Nature generate and analyze, for the first time, the network of ∼100,000 membrane contacts between neurons in the C. elegans nerve ring. These novel data, extracted from legacy electron microscographs, represent a shif...
We present an automated method to track and identify neurons in , called 'fast Deep Neural Correspondence' or fDNC, based on the transformer network architecture. The model is trained once on empirically derived semi-synthetic data and then predicts ...
Efficient and precise base editors (BEs) for C-to-G transversion are highly desirable. However, the sequence context affecting editing outcome largely remains unclear. Here we report engineered C-to-G BEs of high efficiency and fidelity, with the seq...
UNLABELLED: Essential genes are critical for the growth and survival of any organism. The machine learning approach complements the experimental methods to minimize the resources required for essentiality assays. Previous studies revealed the need to...