AIMC Topic: Chemokine CCL5

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Integrative network pharmacology and multi-omics reveal anisodamine hydrobromide's multi-target mechanisms in sepsis.

Scientific reports Jul 31, 2025
Sepsis, marked by hyperinflammation and subsequent immunosuppression, lacks effective phase-specific therapies. Although anisodamine hydrobromide (Ani HBr) reduced 28-day mortality in our prior trial, its mechanisms remained unclear. Here, we integra...
Humans Animals Male Molecular Docking Simulation Sepsis Protein Interaction Maps Multiomics Chemokine CCL5 Network Pharmacology Solanaceous Alkaloids
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Immune-Based Prediction of COVID-19 Severity and Chronicity Decoded Using Machine Learning.

Frontiers in immunology Jun 28, 2021
Expression of CCR5 and its cognate ligands have been implicated in COVID-19 pathogenesis, consequently therapeutics directed against CCR5 are being investigated. Here, we explored the role of CCR5 and its ligands across the immunologic spectrum of CO...
Humans Machine Learning COVID-19 Algorithms Prognosis Female SARS-CoV-2 Male Severity of Illness Index Case-Control Studies Lymphocyte Activation Antibodies, Viral Computational Biology CD8-Positive T-Lymphocytes Post-Acute COVID-19 Syndrome RNA, Viral T-Lymphocytes, Regulatory Receptors, CCR5 Chemokine CCL5
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