AIMC Topic: Colchicine

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Discovery of Novel 4,5-Dihydropyrrolo[3,4-]pyrazol-6()-one-Based Tubulin Inhibitors Targeting Colchicine Binding Site with Potent Anti-Ovarian Cancer Activity.

Journal of medicinal chemistry Sep 20, 2025
To address the toxicity of current microtubule inhibitors, we employed the GeminiMol deep learning model to screen the Zinc20 database, identifying a novel 4,5-dihydropyrrolo[3,4-]pyrazol-6(2)-one scaffold () targeting the colchicine binding site. Su...
Humans Female Animals Drug Discovery Antineoplastic Agents Cell Line, Tumor Mice Cell Proliferation Mice, Nude Apoptosis Ovarian Neoplasms Drug Screening Assays, Antitumor Structure-Activity Relationship Xenograft Model Antitumor Assays Pyrazoles Tubulin Binding Sites Colchicine Tubulin Modulators
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Long-Term Efficacy of Colchicine in Patients With Chronic Coronary Disease: Insights From LoDoCo2.

Circulation Feb 21, 2022
Humans Female Aged Aged, 80 and over Adult Male Middle Aged Coronary Artery Disease Colchicine
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Efficacy and safety of a fixed combination of intramuscular diclofenac 75 mg + thiocolchicoside 4 mg in the treatment of acute low back pain: a phase III, randomized, double blind, controlled trial.

European journal of physical and rehabilitation medicine Dec 21, 2017
BACKGROUND: The management of acute low back pain (LBP) is directed to obtain early and maximum relief of the local and regional pain, and to improve mobility and physical function.
Humans Female Male Middle Aged Treatment Outcome Drug Combinations Pain Measurement Double-Blind Method Italy Low Back Pain Injections, Intramuscular Colchicine Diclofenac
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