AIMC Topic: Computational Biology
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Anticancer drug response prediction integrating multi-omics pathway-based difference features and multiple deep learning techniques.
PLoS computational biology
Mar 31, 2025
Individualized prediction of cancer drug sensitivity is of vital importance in precision medicine. While numerous predictive methodologies for cancer drug response have been proposed, the precise prediction of an individual patient's response to drug...
Predicting protein-protein interaction with interpretable bilinear attention network.
Computer methods and programs in biomedicine
Mar 30, 2025
BACKGROUND AND OBJECTIVE: Protein-protein interactions (PPIs) play the key roles in myriad biological processes, helping to understand the protein function and disease pathology. Identification of PPIs and their interaction types through wet experime...
SGA-Driven feature selection and random forest classification for enhanced breast cancer diagnosis: A comparative study.
Scientific reports
Mar 30, 2025
In this study, we propose a novel approach for breast cancer classification that integrates the Seagull Optimization Algorithm (SGA) for feature selection with the Random Forest (RF) classifier for effective data classification. The novelty of our ap...
N6-methyladenine identification using deep learning and discriminative feature integration.
BMC medical genomics
Mar 29, 2025
N6-methyladenine (6 mA) is a pivotal DNA modification that plays a crucial role in epigenetic regulation, gene expression, and various biological processes. With advancements in sequencing technologies and computational biology, there is an increasin...
Amogel: a multi-omics classification framework using associative graph neural networks with prior knowledge for biomarker identification.
BMC bioinformatics
Mar 28, 2025
The advent of high-throughput sequencing technologies, such as DNA microarray and DNA sequencing, has enabled effective analysis of cancer subtypes and targeted treatment. Furthermore, numerous studies have highlighted the capability of graph neural ...
SIMVI disentangles intrinsic and spatial-induced cellular states in spatial omics data.
Nature communications
Mar 27, 2025
Spatial omics technologies enable analysis of gene expression and interaction dynamics in relation to tissue structure and function. However, existing computational methods may not properly distinguish cellular intrinsic variability and intercellular...
SGCLMD: Signed graph-based contrastive learning model for predicting somatic mutation-drug association.
Computers in biology and medicine
Mar 26, 2025
Somatic mutations could influence critical cellular processes, leading to uncontrolled cell growth and tumor formation. Understanding the intricate interactions between somatic mutations and drugs was crucial for advancing our knowledge of the underl...
Integrating bioinformatics and machine learning for comprehensive analysis and validation of diagnostic biomarkers and immune cell infiltration characteristics in pediatric septic shock.
Scientific reports
Mar 26, 2025
This study aims to predict and diagnose pediatric septic shock through the screening of immune infiltration-related biomarkers. Three gene expression datasets were accessible from the Gene Expression Omnibus repository. The differentially expressed g...
Integrating machine learning and multi-omics analysis to reveal nucleotide metabolism-related immune genes and their functional validation in ischemic stroke.
Frontiers in immunology
Mar 26, 2025
BACKGROUND: Ischemic stroke (IS) is a major global cause of death and disability, linked to nucleotide metabolism imbalances. This study aimed to identify nucleotide metabolism-related genes associated with IS and explore their roles in disease mecha...
New Insights Into the Correlation Between Necroptotic Activation and Neutrophil Infiltration in Pulpitis.
International dental journal
Mar 25, 2025
BACKGROUND: Pulpitis is a significant dental concern characterized by inflammation of the dental pulp, often causing severe pain and potential tooth loss. Immune infiltration and necroptosis, both implicated in various inflammatory conditions, have b...
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