Methods in molecular biology (Clifton, N.J.)
Jan 1, 2022
The dramatic convergence of molecular biology, genomics, proteomics, metabolomics, bioinformatics, and artificial intelligence has provided a substrate for deep understanding of the biological basis of health and disease. Systems biology is a holisti...
Journal of computational biology : a journal of computational molecular cell biology
Jan 1, 2022
We propose GRNUlar, a novel deep learning framework for supervised learning of gene regulatory networks (GRNs) from single-cell RNA-Sequencing (scRNA-Seq) data. Our framework incorporates two intertwined models. First, we leverage the expressive abil...
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2022
The results of high-throughput experiments consist of numerous candidate genes, proteins, or other molecules potentially associated with diseases. A challenge for omics science is the knowledge extraction from the results and the filtering of promisi...
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
Jan 1, 2022
As the last decade of human genomics research begins to bear the fruit of advancements in precision medicine, it is important to ensure that genomics' improvements in human health are distributed globally and equitably. An important step to ensuring ...
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
Jan 1, 2022
Application of artificial intelligence (AI) in precision oncology typically involves predicting whether the cancer cells of a patient (previously unseen by AI models) will respond to any of a set of existing anticancer drugs, based on responses of pr...
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
Jan 1, 2022
As deep learning plays an increasing role in making medical decisions, explainability is playing an increasing role in satisfying regulatory requirements and facilitating trust and transparency in deep learning approaches. In cardiac imaging, the tas...
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
Jan 1, 2022
The continued generation of large amounts of data within healthcare-from imaging to electronic medical health records to genomics and multi-omics -necessitates tools and methods to parse and interpret these data to improve healthcare outcomes. Artifi...
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
Jan 1, 2022
The last few years mark dramatic improvements in modeling of protein structure. Progress was initially due to breakthroughs in residue-residue contact prediction, first with global statistical models and later with deep learning. These advancements w...
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2022
Reverse vaccinology (RV) is the state-of-the-art vaccine development strategy that starts with predicting vaccine antigens by bioinformatics analysis of the whole genome of a pathogen of interest. Vaxign is the first web-based RV vaccine prediction m...
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