Nucleic acids research
Jul 27, 2020
Nucleotide variants can cause functional changes by altering protein-RNA binding in various ways that are not easy to predict. This can affect processes such as splicing, nuclear shuttling, and stability of the transcript. Therefore, correct modeling...
Annual review of neuroscience
Jul 8, 2020
Significant experimental, computational, and theoretical work has identified rich structure within the coordinated activity of interconnected neural populations. An emerging challenge now is to uncover the nature of the associated computations, how t...
Journal of the American Medical Informatics Association : JAMIA
Jul 1, 2020
OBJECTIVE: Coordination ellipsis is a linguistic phenomenon abound in medical text and is challenging for concept normalization because of difficulty in recognizing elliptical expressions referencing 2 or more entities accurately. To resolve this bot...
Bioinformatics (Oxford, England)
Jul 1, 2020
MOTIVATION: Protein model quality estimation, in many ways, informs protein structure prediction. Despite their tight coupling, existing model quality estimation methods do not leverage inter-residue distance information or the latest technological b...
GigaScience
Jul 1, 2020
BACKGROUND: Gene expression plays a key intermediate role in linking molecular features at the DNA level and phenotype. However, owing to various limitations in experiments, the RNA-seq data are missing in many samples while there exist high-quality ...
IEEE transactions on nanobioscience
Jul 1, 2020
Studying the similarity of diseases can help us to explore the pathological characteristics of complex diseases, and help provide reliable reference information for inferring the relationship between new diseases and known diseases, so as to develop ...
IET systems biology
Jun 1, 2020
Breast cancer is the second leading cause of death in the world. Breast cancer research is focused towards its early prediction, diagnosis, and prognosis. Breast cancer can be predicted on omics profiles, clinical tests, and pathological images. The ...
Bioinformatics (Oxford, England)
Jun 1, 2020
MOTIVATION: Protein domains are subunits that can fold and function independently. Correct domain boundary assignment is thus a critical step toward accurate protein structure and function analyses. There is, however, no efficient algorithm available...
Bioinformatics (Oxford, England)
Jun 1, 2020
MOTIVATION: Protein structural annotations (PSAs) are essential abstractions to deal with the prediction of protein structures. Many increasingly sophisticated PSAs have been devised in the last few decades. However, the need for annotations that are...
Bioinformatics (Oxford, England)
Jun 1, 2020
MOTIVATION: The Protein Data Bank (PDB), the ultimate source for data in structural biology, is inherently imbalanced. To alleviate biases, virtually all structural biology studies use nonredundant (NR) subsets of the PDB, which include only a fracti...