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[Evaluation of the efficacy of antifibrotic drugs on cell cultures in Salzmann's nodular degeneration].

Vestnik oftalmologii
UNLABELLED: Excessive production of extracellular matrix is a key component in the pathogenesis of Salzmann's nodular degeneration (SND). studies of drugs that suppress excessive fibroblast activity may become crucial in developing pathogenetically ...

Effect of Oregon grape root extracts on P-glycoprotein mediated transport in cell lines.

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques
This study aims to investigate the potential of Oregon grape root extracts to modulate the activity of P-glycoprotein. We performed H-CsA or H-digoxin transport experiments in the absence or presence of two sources of Oregon grape root extracts (E1...

The use of natural language processing on narrative medication schedules to compute average weekly dose.

Pharmacoepidemiology and drug safety
PURPOSE: Medications with non-standard dosing and unstandardized units of measurement make the estimation of prescribed dose difficult from pharmacy dispensing data. A natural language processing tool named the SIG extractor was developed to identify...

An artificial neural network-pharmacokinetic model and its interpretation using Shapley additive explanations.

CPT: pharmacometrics & systems pharmacology
We developed a method to apply artificial neural networks (ANNs) for predicting time-series pharmacokinetics (PKs), and an interpretable the ANN-PK model, which can explain the evidence of prediction by applying Shapley additive explanations (SHAP). ...