International journal of pharmaceutics
Nov 25, 2025
Defining suspension stability can be extremely complex, but beyond critical during the formulation development of nano- and microsuspensions intended for long-acting injectables. As of now, the current practice is based on the trial-and-error approac...
Journal of controlled release : official journal of the Controlled Release Society
Nov 17, 2025
Long-acting injectables (LAIs) represent promising drug delivery platforms for chronic diseases management, but their clinical translation remains constrained by extremely long trial-and-error experiments (8-10 years), limited mechanism insights, and...
International journal of pharmaceutics
Sep 26, 2025
The advancement of sustainable and biocompatible materials has opened new avenues in drug delivery systems, especially through the integration of plant-based nanofiber biocomposites. These materials, derived from renewable sources such as cellulose, ...
International journal of pharmaceutics
Jun 25, 2025
Polymer microparticles (MPs) have long been a cornerstone of long-acting injectable (LAI) drug delivery, offering controlled drug release, reduced dosing frequency, and improved patient adherence. Among these, poly(lactide-co-glycolide) (PLGA)-based ...
This study aims to optimize ibuprofen-based Drug Delivery Systems (DDSs) to address their short half-life and enhance controlled release. Advanced machine learning techniques, including Artificial Neural Networks, Random Forest, and CatBoost, were em...
Journal of controlled release : official journal of the Controlled Release Society
Apr 21, 2025
Long-acting injectable (LAI) formulations, which deliver drugs over weeks or months, have been in use for more than three decades. Most clinically approved LAI products are formulated using poly(lactide-co-glycolide) (PLGA) polymers. Historically, th...
The study is based on applying Artificial Neural Network (ANN) based machine learning and Response Surface Methodology (RSM) as simultaneous bivariate approaches in developing controlled-release rivaroxaban (RVX) osmotic tablets. The influence of dif...
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Nov 28, 2024
This study proposes a novel non-linear modelling approach to predict the dissolution profiles of extended-release tablets, by combining a full-factorial design, curve fitting to the dissolution profiles, and artificial neural networks (ANN), with lin...
Controlled release of a desired drug from porous polymeric biomaterials was analyzed via computational method. The method is based on simulation of mass transfer and utilization of artificial intelligence (AI). This study explores the efficacy of thr...
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Sep 11, 2024
Gastroretentive dosage forms are recommended for several active substances because it is often necessary for the drug to be released from the carrier system into the stomach over an extended period. Among gastroretentive dosage forms, floating tablet...
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