Diabetic foot ulcers (DFUs) are a severe complication of diabetes, characterized by impaired wound healing, chronic inflammation, and tissue degradation. N-methyladenosine (mA), has emerged as a critical regulator in gene expression and cellular func...
BACKGROUND: Diabetic foot complications are among the most severe and costly outcomes associated with diabetes, with high prevalence particularly in the Middle East and North Africa region. Current screening tools are often limited by subjectivity, i...
Background A major complication of diabetes, diabetic foot ulcers (DFU), has been linked to mitochondrial dysfunction and oxidative stress. Here, we performed analysis of RNA sequencing data from publicly available databases, including single-cell as...
BACKGROUND: Peripheral arterial disease (PAD) and local infections increase the risk of non-healing diabetic foot ulcers (DFU) and limb amputations but are treatable by percutaneous transluminal angioplasty (PTA), local wound care and antibiotic ther...
STUDY OBJECTIVES: Chronic wounds represent a significant economic and personal burden. For their successful treatment, the causes must be known and treated. Wounds caused by pyoderma gangrenosum (PG), a rare inflammatory skin disease, are often misdi...
BACKGROUND: Machine learning (ML) has shown great potential in recognizing complex disease patterns and supporting clinical decision-making. Diabetic foot ulcers (DFUs) represent a significant multifactorial medical problem with high incidence and se...
BACKGROUND: Diabetes-related foot ulceration (DFU) is a common complication of diabetes, with a significant impact on survival, health care costs, and health-related quality of life. The prognosis of DFU varies widely among individuals. The Internati...
Diabetic Foot Ulcer (DFU) is a major complication of diabetes which needs early detection to help in timely treatment for preventing future serious consequences. Due to peripheral neuropathy, high blood glucose levels, and untreated wounds, DFUs can ...
Journal of neuroengineering and rehabilitation
Jul 18, 2025
The diabetic foot (DF) is a chief culprit behind significant preventable morbidity and mortality in type-2-diabetes patients and the leading cause of non-traumatic lower-extremity amputations. Despite the clinically well-understood pathways to ulcera...
BACKGROUND: Oxidative stress plays a crucial role in the development of diabetic foot ulcers (DFU). However, its underlying mechanisms are not fully understood. The purpose of this study was to use bioinformatics and preliminary validation methods to...
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