Medical & biological engineering & computing
Mar 18, 2022
Computer-aided rational vaccine design (RVD) and synthetic pharmacology are rapidly developing fields that leverage existing datasets for developing compounds of interest. Computational proteomics utilizes algorithms and models to probe proteins for ...
Journal of bioinformatics and computational biology
Mar 9, 2022
Enhancers are short regulatory DNA fragments that are bound with proteins called activators. They are free-bound and distant elements, which play a vital role in controlling gene expression. It is challenging to identify enhancers and their strength ...
Even though there were many tool developments of fusion gene prediction from NGS data, too many false positives are still an issue. Wise use of the genomic features around the fusion gene breakpoints will be helpful to identify reliable fusion genes ...
MOTIVATION: DNA N6-methyladenine (6mA) is a pivotal DNA modification for various biological processes. More accurate prediction of 6mA methylation sites plays an irreplaceable part in grasping the internal rationale of related biological activities. ...
IEEE/ACM transactions on computational biology and bioinformatics
Feb 3, 2022
It is well-known that the major reason for the rapid proliferation of cancer cells are the hypomethylation of the whole cancer genome and the hypermethylation of the promoter of particular tumor suppressor genes. Locating 5-methylcytosine (5mC) sites...
DNA N4-methylcytosine (4mC) is an important DNA modification and plays a crucial role in a variety of biological processes. Accurate 4mC site identification is fundamental to improving the understanding of 4mC biological functions and mechanisms. How...
This paper presents novel implementations for reservoir computing (RC) using DNA . An RC system consists of two parts: and . The reservoir projects input signals into a high-dimensional feature space which is formed by the of the reservoir. The int...
Neural networks : the official journal of the International Neural Network Society
Dec 23, 2021
Neural network architectures are high-performing variable models that can solve many learning tasks. Designing architectures manually require substantial time and also prior knowledge and expertise to develop a high-accuracy model. Most of the archit...
Angewandte Chemie (International ed. in English)
Dec 23, 2021
Manipulation of cell-cell interactions via cell surface engineering has potential biomedical applications in tissue engineering and cell therapy. However, manipulation of the comprehensive and multiple intercellular interactions remains a challenge a...
Clinical metagenomics is a powerful diagnostic tool, as it offers an open view into all DNA in a patient's sample. This allows the detection of pathogens that would slip through the cracks of classical specific assays. However, due to this unspecific...