Quantum transport-based DNA sequencing is emerging as a promising technique in genetic analysis, offering fast, precise, and scalable decoding of genetic information, holding significant potential for applications in human biology and personalized me...
Quantum tunneling-based DNA sequencing promises to transform genomic analysis by improving long-read accuracy and enabling high-throughput sequencing, particularly the precise measurement of electrical conductance and tunneling current signatures ass...
DNA metabolism genes play pivotal roles in the regulation of cellular processes that contribute to cancer progression, immune modulation, and therapeutic response in prostate cancer (PC). Understanding the mechanisms by which these genes influence th...
DNA is a promising medium for digital data storage due to its exceptional data density and longevity. Practical DNA-based storage systems require selective data retrieval to minimize decoding time and costs. In this work, we introduce CRISPR-Cas9 as ...
G-quadruplexes (GQs) are non-canonical DNA structures encoded by G-flipons with potential roles in gene regulation and chromatin structure. Here, we explore the role of G-flipons in tissue specification. We present a deep learning-based framework for...
DNA storage has been widely considered as a promising alternative for exponentially growing data. However, the inherent complex secondary structures severely compromise the processes of synthesis, PCR amplification, and sequencing, interfering with r...
DNA topology is essential for regulating cellular processes and maintaining genome stability, yet it is challenging to quantify due to the size and complexity of topologically constrained DNA molecules. By combining high-resolution Atomic Force Micro...
Protein engineering has recently seen tremendous transformation due to machine learning (ML) tools that predict structure from sequence at unprecedented precision. Predicting catalytic activity, however, remains challenging, restricting our capabilit...
Noninvasive odor sensing is important in environmental monitoring and medical diagnosis. The two-dimensional material MXene is widely used due to its unique sensing properties but has limitations in specifically recognizing a certain gas. This study ...
Journal of the American Chemical Society
Jun 17, 2025
The translocation of DNA in polymerase (Pol) enzymes is a critical step for Pol-mediated nucleic acid polymerization, essential for storing and transmitting genetic information in all living organisms. During this process, the newly elongated double-...
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