AIMC Topic: Dose-Response Relationship, Drug

Clear Filters Showing 181 to 186 of 186 articles

Antigenotoxic and apoptotic activities of essential oil of Correa.

Indian journal of pharmacology Jan 1, 2016
OBJECTIVE: To study antigenotoxic and apoptotic activities of hydrodistilled essential oil from the leaves of Correa.
DNA Damage HeLa Cells Dose-Response Relationship, Drug Rutaceae 3T3-L1 Cells Mutagenicity Tests Hydrogen Peroxide Humans Mice Oils, Volatile Plant Extracts Animals Cell Proliferation Apoptosis
View on PubMed DOI

[Bovine lactoferrin decreases the invasion of Salmonella enterica to HEp-2 cells].

Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru Jan 1, 2016
OBJECTIVE: To assess the effect of bovine lactoferrin (bLf) on the invasion of Salmonella enterica ser. Typhimurium to HEp-2 cells.
Humans Animals Virulence Lactoferrin Dose-Response Relationship, Drug Salmonella typhimurium Cell Line, Tumor Cattle
View on PubMed

Pharmacokinetics of Amitriptyline HCl and Its Metabolites in Healthy African Grey Parrots ( Psittacus erithacus ) and Cockatoos (Cacatua Species).

Journal of avian medicine and surgery Dec 1, 2015
Amitriptyline, a tricyclic antidepressant, is used clinically to treat feather-destructive behavior in psittacine birds at a recommended dosage of 1-5 mg/kg PO q12-24h, which has been extrapolated from human medicine and based on anecdotal reports. T...
Species Specificity Adrenergic Uptake Inhibitors Half-Life Cockatoos Amitriptyline Parrots Animals Dose-Response Relationship, Drug
View on PubMed DOI

Identification of a Selective G1-Phase Benzimidazolone Inhibitor by a Senescence-Targeted Virtual Screen Using Artificial Neural Networks.

Neoplasia (New York, N.Y.) Sep 1, 2015
Cellular senescence is a barrier to tumorigenesis in normal cells, and tumor cells undergo senescence responses to genotoxic stimuli, which is a potential target phenotype for cancer therapy. However, in this setting, mixed-mode responses are common ...
User-Computer Interface Gene Regulatory Networks Humans Neural Networks, Computer HCT116 Cells Benzimidazoles G1 Phase Dose-Response Relationship, Drug Cellular Senescence
View on PubMed DOI

Spontaneous withdrawal in intermittent morphine administration in rats and mice: effect of clonidine coadministration and sex-related differences.

Turkish journal of medical sciences Jan 1, 2015
BACKGROUND/AIM: Treating animals repeatedly with intermittent and increasing morphine doses has been suggested to allow some withdrawal during each dosing interval, which causes repeated stress. The present study aimed to test this hypothesis and ass...
Narcotic Antagonists Substance Withdrawal Syndrome Mice, Inbred Strains Naloxone Clonidine Analgesics Female Grooming Mice, Inbred BALB C Animals Analgesics, Opioid Dose-Response Relationship, Drug Sex Factors Morphine Male Drug Administration Schedule Rats, Wistar
View on PubMed

Compressed images for affinity prediction-2 (CIFAP-2): an improved machine learning methodology on protein-ligand interactions based on a study on caspase 3 inhibitors.

Journal of enzyme inhibition and medicinal chemistry Jan 1, 2015
The aim of this study is to propose an improved computational methodology, which is called Compressed Images for Affinity Prediction-2 (CIFAP-2) to predict binding affinities of structurally related protein-ligand complexes. CIFAP-2 method is establi...
Humans Machine Learning Molecular Structure Sulfonamides Regression Analysis Dose-Response Relationship, Drug Ligands Caspase 3 Structure-Activity Relationship Enzyme Inhibitors
View on PubMed DOI
Popular Topics
Recent Journals