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Drug Resistant Epilepsy

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Electroclinical spectrum of generalized paroxysmal fast activity in adults without epileptic encephalopathy.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
INTRODUCTION: Generalized paroxysmal fast activity (GPFA) is a rare and underreported EEG pattern known to be related to epileptic encephalopathy. We aimed to investigate the electroclinical spectrum of GPFA along with other atypical EEG features in ...

Neuromagnetic high frequency spikes are a new and noninvasive biomarker for localization of epileptogenic zones.

Seizure
OBJECTIVE: One barrier hindering high frequency brain signals (HFBS, >80 Hz) from wide clinical applications is that the brain generates both pathological and physiological HFBS. This study was to find specific biomarkers for localizing epileptogenic...

Neurosurgical robot-assistant stereoelectroencephalography system: Operability and accuracy.

Brain and behavior
BACKGROUND: Fine operation has been an eternal topic in neurosurgery. There were many problems in functional neurosurgery field with high precision requirements. Our study aims to explore the operability, accuracy and postoperative effect of robot-as...

Robot-assisted stereoelectroencephalography in young children: technical challenges and considerations.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
Robot-assisted stereoelectroencephalography (sEEG) is frequently employed to localize epileptogenic zones in patients with medically refractory epilepsy (MRE). Its methodology is well described in adults, but less so in children. Given the limited in...

A simulation study to investigate the use of concentric tube robots for epilepsy surgery.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
PURPOSE: Patients with pharmacoresistant refractory epilepsy may require epilepsy surgery to prevent future seizure occurrences. Conventional surgery consists of a large craniotomy with straight rigid tools with associated outcomes of morbidity, larg...

A neuromorphic spiking neural network detects epileptic high frequency oscillations in the scalp EEG.

Scientific reports
Interictal High Frequency Oscillations (HFO) are measurable in scalp EEG. This development has aroused interest in investigating their potential as biomarkers of epileptogenesis, seizure propensity, disease severity, and treatment response. The deman...

Robot-assisted, real-time, MRI-guided laser interstitial thermal therapy for pediatric patients with hypothalamic hamartoma: surgical technique, pitfalls, and initial results.

Journal of neurosurgery. Pediatrics
OBJECTIVE: Real-time, MRI-guided laser interstitial thermal therapy (MRgLITT) has been reported as a safe and effective technique for the treatment of epileptogenic foci in children and adults. After the recent approval of MRgLITT by the European Med...

Deep learning resting state functional magnetic resonance imaging lateralization of temporal lobe epilepsy.

Epilepsia
OBJECTIVE: Localization of focal epilepsy is critical for surgical treatment of refractory seizures. There remains a great need for noninvasive techniques to localize seizures for surgical decision-making. We investigate the use of deep learning usin...

SEEG-Net: An explainable and deep learning-based cross-subject pathological activity detection method for drug-resistant epilepsy.

Computers in biology and medicine
OBJECTIVE: Precise preoperative evaluation of drug-resistant epilepsy (DRE) requires accurate analysis of invasive stereoelectroencephalography (SEEG). With the tremendous breakthrough of Artificial intelligence (AI), previous studies can help clinic...

Multi-Scale Deep Learning of Clinically Acquired Multi-Modal MRI Improves the Localization of Seizure Onset Zone in Children With Drug-Resistant Epilepsy.

IEEE journal of biomedical and health informatics
The present study investigates the effectiveness of a deep learning neural network for non-invasively localizing the seizure onset zone (SOZ) using multi-modal MRI data that are clinically acquired from children with drug-resistant epilepsy. A cortic...