AIMC Topic: Drug Resistant Epilepsy

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The interaction of UBR4, LRP1, and OPHN1 in refractory epilepsy: Drosophila model to investigate the oligogenic effect on epilepsy.

Neurobiology of disease
Refractory epilepsy is an intractable neurological disorder that can be associated with oligogenic/polygenic etiologies. Through trio-based whole-exome sequencing analysis, we identified a clinical case of refractory epilepsy with three candidate gen...

Automated Whole-Brain Focal Cortical Dysplasia Detection Using MR Fingerprinting With Deep Learning.

Neurology
BACKGROUND AND OBJECTIVES: Focal cortical dysplasia (FCD) is a common pathology for pharmacoresistant focal epilepsy, yet detection of FCD on clinical MRI is challenging. Magnetic resonance fingerprinting (MRF) is a novel quantitative imaging techniq...

Predicting seizure onset zones from interictal intracranial EEG using functional connectivity and machine learning.

Scientific reports
Functional connectivity (FC) analyses of intracranial EEG (iEEG) signals can potentially improve the mapping of epileptic networks in drug-resistant focal epilepsy. However, it remains unclear whether FC-based metrics provide additional value beyond ...

[Safety of robot-assisted implantation of deep electrodes for invasive stereo-EEG monitoring].

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko
UNLABELLED: Robot-assisted implantation of deep electrodes for stereo-EEG monitoring has become popular in recent years in patients with drug-resistant epilepsy. However, there are still few data on safety of this technique.

Classifying cross-frequency coupling pattern in epileptogenic tissues by convolutional neural network.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
The phase-amplitude coupling in EEG signal of different frequencies is considered as a useful biomarker in delineating epileptogenic tissues, but some physiological processes can also generate phase-amplitude coupling pattern, such as memory process....

Robot-assisted stereoelectroencephalography exploration of the limbic thalamus in human focal epilepsy: implantation technique and complications in the first 24 patients.

Neurosurgical focus
OBJECTIVE: Despite numerous imaging studies highlighting the importance of the thalamus in a patient's surgical prognosis, human electrophysiological studies involving the limbic thalamic nuclei are limited. The objective of this study was to evaluat...