AIMC Topic: GTPase-Activating Proteins

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Machine learning models reveal ARHGAP11A's impact on lymph node metastasis and stemness in NSCLC.

BioFactors (Oxford, England) Oct 31, 2024
Most patients with non-small cell lung cancer (NSCLC) are diagnosed at an advanced stage of the disease, which complicates treatment due to a heightened risk of metastasis. Consequently, the timely identification of biomarkers associated with lymph n...
Machine Learning Prognosis Female Humans Gene Expression Regulation, Neoplastic Cell Proliferation Carcinoma, Non-Small-Cell Lung Neoplastic Stem Cells Lymphatic Metastasis Biomarkers, Tumor GTPase-Activating Proteins Male Middle Aged Cell Line, Tumor Lung Neoplasms
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Integrating bioinformatics and machine learning methods to analyze diagnostic biomarkers for HBV-induced hepatocellular carcinoma.

Diagnostic pathology Aug 2, 2024
Hepatocellular carcinoma (HCC) is a malignant tumor. It is estimated that approximately 50-80% of HCC cases worldwide are caused by hepatitis b virus (HBV) infection, and other pathogenic factors have been shown to promote the development of HCC when...
Hepatitis B Computational Biology Gene Expression Regulation, Neoplastic Carcinoma, Hepatocellular Hepatitis B virus Databases, Genetic GTPase-Activating Proteins Humans Machine Learning Biomarkers, Tumor Gene Expression Profiling Liver Neoplasms
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RACGAP1 is a pivotal gene in lung adenocarcinoma-associated membranous nephropathy: Based on comprehensive bioinformatics analysis and machine learning.

International immunopharmacology Jul 27, 2024
BACKGROUND: This study performs a detailed bioinformatics and machine learning analysis to investigate the genetic foundations of membranous nephropathy (MN) in lung adenocarcinoma (LUAD).
GTPase-Activating Proteins Glomerulonephritis, Membranous Collagen Type III Adenocarcinoma of Lung Gene Expression Regulation, Neoplastic Databases, Genetic Female Male Middle Aged Gene Expression Profiling Lung Neoplasms Computational Biology Humans Machine Learning Prognosis
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Identification of DEP domain-containing proteins by a machine learning method and experimental analysis of their expression in human HCC tissues.

Scientific reports Dec 21, 2016
The Dishevelled/EGL-10/Pleckstrin (DEP) domain-containing (DEPDC) proteins have seven members. However, whether this superfamily can be distinguished from other proteins based only on the amino acid sequences, remains unknown. Here, we describe a com...
Computational Biology RNA, Messenger Gene Expression Regulation, Neoplastic Real-Time Polymerase Chain Reaction Amino Acid Motifs Signal Transduction Phylogeny Liver Neoplasms GTPase-Activating Proteins Cluster Analysis Humans Gene Expression Profiling Carcinoma, Hepatocellular Dishevelled Proteins Machine Learning Protein Domains Algorithms
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Machine Learning-based Classification of Diffuse Large B-cell Lymphoma Patients by Their Protein Expression Profiles.

Molecular & cellular proteomics : MCP Aug 26, 2015
Characterization of tumors at the molecular level has improved our knowledge of cancer causation and progression. Proteomic analysis of their signaling pathways promises to enhance our understanding of cancer aberrations at the functional level, but ...
Isotope Labeling GTPase-Activating Proteins Neprilysin Gene Expression Regulation, Neoplastic Formaldehyde Phosphoprotein Phosphatases Biomarkers, Tumor Signal Transduction Proteomics Tissue Embedding Humans Neoplasm Proteins Lymphoma, Large B-Cell, Diffuse Apoptosis Regulatory Proteins Proteome Tissue Fixation Machine Learning Principal Component Analysis Cell Line, Tumor
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The interaction of UBR4, LRP1, and OPHN1 in refractory epilepsy: Drosophila model to investigate the oligogenic effect on epilepsy.

Neurobiology of disease Aug 1, 2025
Refractory epilepsy is an intractable neurological disorder that can be associated with oligogenic/polygenic etiologies. Through trio-based whole-exome sequencing analysis, we identified a clinical case of refractory epilepsy with three candidate gen...
Male Disease Models, Animal Animals, Genetically Modified Humans Female Animals Drug Resistant Epilepsy GTPase-Activating Proteins Low Density Lipoprotein Receptor-Related Protein-1 Drosophila Proteins Ubiquitin-Protein Ligases Drosophila
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