Clinical trials are essential for determining whether new interventions are effective. In order to determine the eligibility of patients to enroll into these trials, clinical trial coordinators often perform a manual review of clinical notes in the e...
BMC medical informatics and decision making
Apr 14, 2015
BACKGROUND: Manual eligibility screening (ES) for a clinical trial typically requires a labor-intensive review of patient records that utilizes many resources. Leveraging state-of-the-art natural language processing (NLP) and information extraction (...
Journal of the American Medical Informatics Association : JAMIA
Jul 16, 2014
OBJECTIVES: (1) To develop an automated eligibility screening (ES) approach for clinical trials in an urban tertiary care pediatric emergency department (ED); (2) to assess the effectiveness of natural language processing (NLP), information extractio...
Studies in health technology and informatics
Aug 7, 2025
Clinical trial eligibility criteria, often presented as complex free text, pose significant challenges for automated processing. This study introduces a Decomposition and Parsing (DP) workflow to address these challenges by systematically breaking do...
Journal of the American Medical Informatics Association : JAMIA
Mar 1, 2025
OBJECTIVES: Clinical trials (CTs) are essential for improving patient care by evaluating new treatments' safety and efficacy. A key component in CT protocols is the study population defined by the eligibility criteria. This study aims to evaluate the...
Studies in health technology and informatics
Jan 25, 2024
Artificial Intelligence (AI) has great potential to improve healthcare, but implementation into routine practice remains a challenge. This study scoped the extent to which AI and Natural Language Processing (NLP) is being implemented into routine pra...
Journal of the American Medical Informatics Association : JAMIA
Jan 18, 2024
OBJECTIVES: We aim to build a generalizable information extraction system leveraging large language models to extract granular eligibility criteria information for diverse diseases from free text clinical trial protocol documents. We investigate the ...
PURPOSE: Matching patients to clinical trials is cumbersome and costly. Attempts have been made to automate the matching process; however, most have used a trial-centric approach, which focuses on a single trial. In this study, we developed a patient...
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