AIMC Topic: Enzymes

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Biocuration in the structure-function linkage database: the anatomy of a superfamily.

Database : the journal of biological databases and curation Jan 1, 2017
UNLABELLED: With ever-increasing amounts of sequence data available in both the primary literature and sequence repositories, there is a bottleneck in annotating molecular function to a sequence. This article describes the biocuration process and met...
Structural Homology, Protein Structure-Activity Relationship Molecular Sequence Annotation Gene Ontology Enzymes Databases, Protein
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Complementary Sources of Protein Functional Information: The Far Side of GO.

Methods in molecular biology (Clifton, N.J.) Jan 1, 2017
The GO captures many aspects of functional annotations, but there are other alternative complementary sources of protein function information. For example, enzyme functional annotations are described in a range of resources from the Enzyme Commission...
Humans Software Computational Biology Signal Transduction Animals Protein Interaction Maps Enzymes Internet Databases, Genetic Proteins Molecular Sequence Annotation Protein Domains Gene Ontology Genome
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Evaluating Functional Annotations of Enzymes Using the Gene Ontology.

Methods in molecular biology (Clifton, N.J.) Jan 1, 2017
The Gene Ontology (GO) (Ashburner et al., Nat Genet 25(1):25-29, 2000) is a powerful tool in the informatics arsenal of methods for evaluating annotations in a protein dataset. From identifying the nearest well annotated homologue of a protein of int...
Animals Computational Biology Humans Gene Ontology Enzymes Databases, Protein Molecular Sequence Annotation
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Challenges and Opportunities for Increasing the Knowledge Base Related to Drug Biotransformation and Pharmacokinetics during Growth and Development.

Drug metabolism and disposition: the biological fate of chemicals Jul 1, 2016
It is generally acknowledged that there is a need and role for informative pharmacokinetic models to improve predictions and simulation as well as individualization of drug therapy in pediatric populations of different ages and developmental stages. ...
Adolescent Development Gene Expression Regulation, Developmental Child, Preschool Child Age Factors Computer Simulation Pharmaceutical Preparations Infant, Newborn Infant Membrane Transport Proteins Adolescent Humans Biotransformation Gene Expression Regulation, Enzymologic Aging Child Development Pharmacokinetics Models, Biological Enzymes Knowledge Bases
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Artificial neural networks for dihedral angles prediction in enzyme loops: a novel approach.

International journal of bioinformatics research and applications Jan 1, 2015
Structure prediction of proteins is considered a limiting step and determining factor in drug development and in the introduction of new therapies. Since the 3D structures of proteins determine their functionalities, prediction of dihedral angles rem...
Protein Structure, Tertiary Models, Chemical Sequence Analysis, Protein Enzymes Computer Simulation Amino Acid Sequence Molecular Sequence Data Models, Molecular Pattern Recognition, Automated Neural Networks, Computer Protein Conformation
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