AIMC Topic: Gene Expression Regulation, Enzymologic

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Selected essential oils inhibit key physiological enzymes and possess intracellular and extracellular antimelanogenic properties in vitro.

Journal of food and drug analysis Apr 20, 2017
Essential oils (EOs) extracted from six medicinal herbs and food plants [Cinnamomum zeylanicum (CZ), Psiadia arguta (PA), Psiadia terebinthina (PT), Citrus grandis (CGp), Citrus hystrix (CH), and Citrus reticulata (CR)] were studied for any inhibitor...
Matrix Metalloproteinase Inhibitors Melanoma, Experimental Hypoglycemic Agents Kinetics Collagenases Oils, Volatile Mice Plant Extracts Melanins Gene Expression Regulation, Enzymologic Biosynthetic Pathways Plants, Medicinal Cholinesterase Inhibitors Enzyme Inhibitors Humans Animals
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Icariin improves eNOS/NO pathway to prohibit the atherogenesis of apolipoprotein E-null mice.

Canadian journal of physiology and pharmacology Dec 22, 2016
Impaired endothelial nitric oxide synthase (eNOS)/nitric oxide (NO) pathway induces atherogenesis. The present study examined whether icariin improves the eNOS/NO pathway to prohibit the atherogenesis of apolipoprotein E-null (ApoE) mice. In vitro, p...
Mice, Inbred C57BL Flavonoids Atherosclerosis Gene Expression Regulation, Enzymologic Apolipoproteins E Gene Deletion Animals Mice Nitric Oxide Nitric Oxide Synthase Type III Humans
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Neuroprotective effects of the Phellinus linteus ethyl acetate extract against H2O2-induced apoptotic cell death of SK-N-MC cells.

Nutrition research (New York, N.Y.) Nov 11, 2015
Numerous studies have suggested that neuronal cells are protected against oxidative stress-induced cell damage by antioxidants, such as polyphenolic compounds. Phellinus linteus (PL) has traditionally been used to treat various symptoms in East Asian...
Neurons Solvents MAP Kinase Signaling System Nerve Tissue Proteins Acetates Polysaccharides Oxidoreductases Ethnopharmacology Medicine, Korean Traditional Basidiomycota Fruiting Bodies, Fungal Gene Expression Regulation, Enzymologic Antioxidants Plant Extracts Neuroprotective Agents Apoptosis Biological Products Polyphenols Republic of Korea Cell Line, Tumor Oxidative Stress Humans Phellinus Brain
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Alkaline phosphatase determines polyphosphate-induced mineralization in a cell-type independent manner.

Journal of bone and mineral metabolism Oct 16, 2015
Polyphosphate [Poly(P)] has positive effects on osteoblast mineralization; however, the underlying mechanism remains unclear. In addition, it is unknown whether Poly(P) promotes mineralization in soft tissues. We investigated this by using various ce...
Polyphosphates Alkaline Phosphatase Rats 3T3-L1 Cells CHO Cells Cricetinae Animals Osteoblasts Cricetulus Gene Expression Regulation, Enzymologic Calcification, Physiologic Mice Organ Specificity
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The Dark Kinase Knowledgebase: an online compendium of knowledge and experimental results of understudied kinases.

Nucleic acids research Jan 8, 2021
Kinases form the backbone of numerous cell signaling pathways, with their dysfunction similarly implicated in multiple pathologies. Further facilitated by their druggability, kinases are a major focus of therapeutic development efforts in diseases su...
Internet Knowledge Bases Gene Expression Regulation, Enzymologic Phosphotransferases
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Altered Expression Patterns of the Sumoylation Enzymes E1, E2 and E3 Are Associated with Glucose Oxidase- and UVA-Induced Cataractogenesis.

Current molecular medicine Jan 1, 2018
PURPOSE: Protein sumoylation is a well established regulatory mechanism that regulates chromatin structure and dynamics, cell proliferation and differentiation, stress response and cell apoptosis. In the vertebrate eye, we and others have shown that ...
Glucose Oxidase Ubiquitin-Activating Enzymes Animals Gene Expression Regulation, Enzymologic Cataract Mice Sumoylation Lens, Crystalline RNA, Messenger Ultraviolet Rays
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Challenges and Opportunities for Increasing the Knowledge Base Related to Drug Biotransformation and Pharmacokinetics during Growth and Development.

Drug metabolism and disposition: the biological fate of chemicals Jul 1, 2016
It is generally acknowledged that there is a need and role for informative pharmacokinetic models to improve predictions and simulation as well as individualization of drug therapy in pediatric populations of different ages and developmental stages. ...
Membrane Transport Proteins Gene Expression Regulation, Enzymologic Child Development Knowledge Bases Adolescent Enzymes Biotransformation Child, Preschool Gene Expression Regulation, Developmental Pharmacokinetics Child Adolescent Development Infant, Newborn Age Factors Humans Aging Pharmaceutical Preparations Computer Simulation Infant Models, Biological
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