AIMC Topic: Epitopes, T-Lymphocyte

Clear Filters Showing 11 to 20 of 33 articles

A robust deep learning workflow to predict CD8 + T-cell epitopes.

Genome medicine Sep 13, 2023
BACKGROUND: T-cells play a crucial role in the adaptive immune system by triggering responses against cancer cells and pathogens, while maintaining tolerance against self-antigens, which has sparked interest in the development of various T-cell-focus...
SARS-CoV-2 Epitopes, T-Lymphocyte Deep Learning CD8-Positive T-Lymphocytes Workflow Humans COVID-19
View on PubMed DOI

HLA-II immunopeptidome profiling and deep learning reveal features of antigenicity to inform antigen discovery.

Immunity Jun 9, 2023
CD4+ T cell responses are exquisitely antigen specific and directed toward peptide epitopes displayed by human leukocyte antigen class II (HLA-II) on antigen-presenting cells. Underrepresentation of diverse alleles in ligand databases and an incomple...
COVID-19 SARS-CoV-2 Epitopes, T-Lymphocyte Peptides Deep Learning HLA Antigens Humans Captan
View on PubMed DOI

T Cell Epitope Prediction and Its Application to Immunotherapy.

Frontiers in immunology Sep 15, 2021
T cells play a crucial role in controlling and driving the immune response with their ability to discriminate peptides derived from healthy as well as pathogenic proteins. In this review, we focus on the currently available computational tools for ep...
Antigen Presentation T-Cell Antigen Receptor Specificity Receptors, Antigen, T-Cell Computational Biology Immunotherapy Antigens, Neoplasm Sequence Analysis, DNA Neural Networks, Computer Mass Spectrometry Neoplasms Models, Molecular Epitopes, T-Lymphocyte Histocompatibility Antigens Class I Peptides Base Sequence Humans
View on PubMed DOI

Utilizing Computational Machine Learning Tools to Understand Immunogenic Breadth in the Context of a CD8 T-Cell Mediated HIV Response.

Frontiers in immunology Feb 18, 2021
Predictive models are becoming more and more commonplace as tools for candidate antigen discovery to meet the challenges of enabling epitope mapping of cohorts with diverse HLA properties. Here we build on the concept of using two key parameters, div...
Epitopes, T-Lymphocyte Peptides HIV Infections Proteome CD8-Positive T-Lymphocytes Humans Machine Learning Genome, Viral Viral Proteins Antigens, Viral HLA Antigens HIV Genetic Variation Host-Pathogen Interactions
View on PubMed DOI

An in silico deep learning approach to multi-epitope vaccine design: a SARS-CoV-2 case study.

Scientific reports Feb 5, 2021
The rampant spread of COVID-19, an infectious disease caused by SARS-CoV-2, all over the world has led to over millions of deaths, and devastated the social, financial and political entities around the world. Without an existing effective medical the...
Humans COVID-19 Vaccines, Subunit T-Lymphocytes, Cytotoxic Codon Usage Mutation Deep Learning RNA, Viral COVID-19 Vaccines Molecular Dynamics Simulation Spike Glycoprotein, Coronavirus Allergens SARS-CoV-2 Computational Biology Epitopes, T-Lymphocyte Models, Molecular Solubility Molecular Docking Simulation Immunogenicity, Vaccine Drug Design T-Lymphocytes, Helper-Inducer Protein Conformation Epitopes, B-Lymphocyte
View on PubMed DOI

Artificial intelligence predicts the immunogenic landscape of SARS-CoV-2 leading to universal blueprints for vaccine designs.

Scientific reports Dec 23, 2020
The global population is at present suffering from a pandemic of Coronavirus disease 2019 (COVID-19), caused by the novel coronavirus Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The goal of this study was to use artificial intellige...
Amino Acid Sequence Haplotypes Immunogenicity, Vaccine Epitopes, T-Lymphocyte COVID-19 Vaccines Spike Glycoprotein, Coronavirus Software Proteomics Pandemics Proteome COVID-19 Humans Mutation Algorithms Machine Learning HLA Antigens SARS-CoV-2 Drug Evaluation, Preclinical Alleles
View on PubMed DOI

Identification and validation of 174 COVID-19 vaccine candidate epitopes reveals low performance of common epitope prediction tools.

Scientific reports Nov 24, 2020
The outbreak of SARS-CoV-2 (2019-nCoV) virus has highlighted the need for fast and efficacious vaccine development. Stimulation of a proper immune response that leads to protection is highly dependent on presentation of epitopes to circulating T-cell...
SARS-CoV-2 Epitopes, T-Lymphocyte Peptides COVID-19 Vaccines Spike Glycoprotein, Coronavirus Computational Biology HLA Antigens Alleles Histocompatibility Antigens Class I Humans Machine Learning COVID-19 Base Sequence Histocompatibility Antigens Class II
View on PubMed DOI

Prediction of Specific TCR-Peptide Binding From Large Dictionaries of TCR-Peptide Pairs.

Frontiers in immunology Aug 25, 2020
Current sequencing methods allow for detailed samples of T cell receptors (TCR) repertoires. To determine from a repertoire whether its host had been exposed to a target, computational tools that predict TCR-epitope binding are required. Currents too...
Signal Transduction Binding Sites Humans Databases, Protein Peptides Ligands Software Protein Interaction Domains and Motifs Deep Learning Antigens T-Lymphocytes Receptors, Antigen, T-Cell Epitopes, T-Lymphocyte Protein Binding
View on PubMed DOI

Unbiased Characterization of Peptide-HLA Class II Interactions Based on Large-Scale Peptide Microarrays; Assessment of the Impact on HLA Class II Ligand and Epitope Prediction.

Frontiers in immunology Aug 5, 2020
Human Leukocyte Antigen class II (HLA-II) molecules present peptides to T lymphocytes and play an important role in adaptive immune responses. Characterizing the binding specificity of single HLA-II molecules has profound impacts for understanding ce...
High-Throughput Screening Assays Protein Array Analysis Humans Binding Sites Antigen Presentation Protein Binding Machine Learning Protein Interaction Domains and Motifs CD4 Antigens Databases, Protein Epitopes, T-Lymphocyte Histocompatibility Antigens Class II HLA Antigens Ligands
View on PubMed DOI

Immunopeptidomic Data Integration to Artificial Neural Networks Enhances Protein-Drug Immunogenicity Prediction.

Frontiers in immunology Jun 23, 2020
Recombinant DNA technology has, in the last decades, contributed to a vast expansion of the use of protein drugs as pharmaceutical agents. However, such biological drugs can lead to the formation of anti-drug antibodies (ADAs) that may result in adve...
Epitopes, T-Lymphocyte Rituximab Mass Spectrometry Peptides Histocompatibility Antigens Class II CD4-Positive T-Lymphocytes Dendritic Cells Humans Infliximab Protein Binding Neural Networks, Computer Antirheumatic Agents Proteomics
View on PubMed DOI
Popular Topics
Recent Journals