AIMC Topic: Excipients

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Development of machine learning models for estimation of disintegration time on fast-disintegrating tablets.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
The disintegration time for solid dosage oral formulations is directly influenced by diverse factors such as molecular properties, physical characteristics, excipient compositions, and formulation-specific attributes. This research addresses the chal...

Application of rheology to hot melt extrusion: Theory and practice.

International journal of pharmaceutics
Hot melt extrusion (HME) has become a key manufacturing method in the pharmaceutical industry for developing novel drug delivery systems, due to its solvent-free nature, ease of operation, and ability to achieve one-step molding and continuous proces...

Enhancing YOLOv8n with Mamba-like linear attention for defect detection and coating thickness analysis of irregular film tablet.

International journal of pharmaceutics
This study presents a real-time system that integrates deep learning and machine vision for defect detection and coating thickness measurement of irregularly shaped film-coated tablets. To overcome the accuracy and speed limitations of the traditiona...

Deep learning-based image classification and quantification models for tablet sticking.

International journal of pharmaceutics
Sticking can significantly affect drug product quality, manufacturing efficiency, and therapeutic efficacy in pharmaceutical tablet manufacturing. This study presents a novel integrated model with a convolutional neural network (CNN) and gray-level c...

Machine Learning Uncovers Food- and Excipient-Drug Interactions.

Cell reports
Inactive ingredients and generally recognized as safe compounds are regarded by the US Food and Drug Administration (FDA) as benign for human consumption within specified dose ranges, but a growing body of research has revealed that many inactive ing...

Application of SeDeM expert systems in preformulation studies of pediatric ibuprofen ODT tablets.

Acta pharmaceutica (Zagreb, Croatia)
Pediatric, ibuprofen containing orodispersible tablets (ODTs) were prepared using the SeDeM expert system methodology. In order to facilitate formulation, directly compressible ibuprofen was employed (Ibuprofen DC 8TM) and characterized using its SeD...